Journal of Cancer Research and Clinical Oncology

, Volume 119, Issue 12, pp 756–758

Chemotherapy for recurrent adeno- and adenoidcystic carcinomas in the head and neck

  • Mamoru Tsukuda
  • Toshiyuki Kokatsu
  • Keiko Ito
  • Izumi Mochimatsu
  • Akira Kubota
  • Shuji Sawaki
Original Papers Clinical Oncology

DOI: 10.1007/BF01195348

Cite this article as:
Tsukuda, M., Kokatsu, T., Ito, K. et al. J Cancer Res Clin Oncol (1993) 119: 756. doi:10.1007/BF01195348

Abstract

We have investigated the effectiveness of chemotherapy for patients with recurrent adeno- and adenoidcystic carcinomas in the head and neck. Fourteen cases received a monthly combination chemotherapy regimen of cyclophosphamide, pirarubicin and cisplatin (CAP therapy). A response rate of 36% (5/14) was achieved. There was one complete response and four partial responses. The median duration of response was 37 months in the complete response case and 16 months (range, 6 to 20) in the partial response cases. The toxicity of this chemotherapy was acceptable. The result demonstrates that CAP therapy is an effective regimen for adeno- and adenoidcystic carcinomas. It may also be available as induction or adjuvant chemotherapy for patients with advanced tumors of these cancers.

Key words

Adeno- and adenoidcystic carcinomasHead and neckCAP therapyResponse

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Mamoru Tsukuda
    • 1
  • Toshiyuki Kokatsu
    • 1
  • Keiko Ito
    • 1
  • Izumi Mochimatsu
    • 1
  • Akira Kubota
    • 1
  • Shuji Sawaki
    • 1
  1. 1.Department of OtorhinolarngologyYokohama City University, School of MedicineYokohamaJapan