The emergence of Lyme disease in a changing environment in North America and Central Europe
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Lyme disease has recently begun to emerge as a significant threat to human health, both in Europe and the United States. Late sequellae, resembling those of neurosyphilis and multiple sclerosis, may occur many years after initial infection. Spontaneous abortion accompanies arthritis, carditis and neuritis as burdensome short-term sequellae. Thousands of new infections are recognized each year on each side of the Atlantic, although reporting may be incomplete. The disease was described in Europe nearly a century ago and named erythema chronicum migrans, but its etiology has only recently been defined. The name “Lyme disease” was coined to describe a particularly intense American focus of disease, but the term has gained wide acceptance on both continents. The identity of the American and European etiological agents involved has yet to be determined.
In America, a deer-associated, often bird-transported tick transmits this mouse-reservoired spirochete. The European situation seems more complex because the vector tick feeds on a greater variety of vertebrates. The reservoir hosts of the spirochete have yet to be determined. The role ofIxodes ricinus and possible other vectors in perpetuating transmission of the European infection remains to be defined. WhetherI. ricinus as well asI. dammini merely serve as a bridge to the human population or are important for the maintenance of the feral cycle remains to be seen.
The capacity of a tick to maintain transmission of Lyme disease spirochetes depends upon a complex set of properties, including competence as a host for the spirochete, a pattern of feeding that focuses on a particular reservoir favored by a pattern of tick activity, during each transmission season, in which nymphs feed before larvae. Transmission would be favored by an environment, such as that of islands, in which the variety of potential reservoir hosts is restricted. Hosts, for example reptiles, that might fail to support growth of the spirochete would serve to dilute effective transmission in nature.
Similarly, the capacity of a vertebrate to maintain the infection requires long-term support of the spirochete in a tissue site accessible to vector ticks, tolerance of repeated feeding by vector ticks and a pattern of host activity that exposes the host to numerous bites.
The intensity of infection depends upon a continuous pattern of transmission in which each generation is infected anew. The rate event in which the vector inherits infection would serve mainly to transport the spirochete to a new site, most effectively by migrating birds.
Due to the dispersed nature of Lyme disease and its recent emergence as an important hazard to health, measures for prophylaxis have only recently been devised. Lyme disease can be treated with antibiotics. But the effectiveness of such therapy depends upon correct and prompt diagnosis; delayed treatment is less effective, presumably because the spirochete becomes sequestered in immune-privileged sites.
- Anderson, J.F., Johnson, R.C., Magnarelli, L.A., Hyde, F.W. (1986) Involvement of birds in the epidemiology of the Lyme disease agentBorellia burgdorferi. Infect. Immun. 51: pp. 394-396
- Aeschlimann, A. (1972) Ixodes ricinus, Linné, 1758 (Ixodoidea; Ixodidae). Essai préliminaire de synthèse sur la biologie de cette espèce en Suisse. Acta Trop. 29: pp. 321-340
- Afzelius, A. (1921) Erythema chronicum migrans. Acta Derm. Venereol. 2: pp. 120-125
- Apitzsch, L. (1967) Zecken- und Virusaktivität im Herdgebiet von Torgelow in den Jahren 1960 bis 1965. Z. Ges. Hyg. 13: pp. 251-267
- Bauch, R.J. (1971) Zur Bionomie vonIxodes ricinus. I. Der Entwicklungszyklus im DDR-Bezirk Magdeburg. Angew. Parasitol. 12: pp. 141-149
- Bauch, R.J. (1972) Zur Bionomie vonIxodes ricinus. II. Die Populations-und Saisondynamik an einigen Lokalitäten des DDR-Bezirkes Magdeburg. Angew. Parasitol. 13: pp. 141-154
- Bauch, R.J. (1973) Zur Bionomie vonIxodes ricinus. III. Die Rolle der freilebenden Kleinsäuger als Larvenwirte im DDR-Bezirk Magdeburg. Angew. Parasitol. 14: pp. 208-213
- Bosler, E.M., Ormiston, B.G., Coleman, J.L., Hanrahan, J.P., Benach, J.L. (1984) Prevalence of the Lyme disease spirochete in populations of white-tailed deer and white-footed mouse. Yale J. Biol. Med. 57: pp. 651-659
- Burgdorfer, W., Barbour, A.D., Hayes, S.F., Benach, J.L., Grunwaldt, E., Davis, J.P. (1982) Lyme disease-a tick-borne spirochetosis?. Science 216: pp. 1317-1319
- Burgdorfer, W., Barbour, A.G., Hayes, S.F., Peter, O., Aeschlimann, A. (1983) Erythema chronicum migrans-a tick-borne spirochetosis?. Acta Trop. 40: pp. 79-83
- Cronon, W. (1983) Changes in the Land: Indians, Colonists, and the Ecology of New England. Hill and Wang, New York
- Donahue, J.G., Piesman, J. and Spielman, A., 1986. Reservoir competence of rodents for Lyme disease spirochetes. Am. J. Trop. Med. Hyg. (in press).
- Gilot, B., Pautou, G., Moncada, E., Ain, G. (1975) Première contribution a l'étude ecologique d'Ixodes ricunus (Linné, 1758) (Acarin,Ixodoidea) dans le Sud-Est de la France. Acta Trop. 32: pp. 223-258
- Gray, J.S. (1984) Studies on the dynamics of active populations of the sheep tick,Ixodes ricinus L. in Co. Wicklow, Ireland. Acarologia 23: pp. 167-178
- Gray, J.S. (1985) Studies on the larval activity of the sheep thickIxodes ricinus L. in Co. Wicklow, Ireland. Exp. Appl. Acarol. 1: pp. 307-316
- Kaufman, W.R. The function of the salivary glands. In: Harris, K.F. eds. (1983) Current Topics in Pathogen Vector Host Research. Praeger Scientific, New York, pp. 215-247
- Knülle, W., Rudolph, D. Humidity relationships and water balance of ticks. In: Obenchain, F.D., Galun, R. eds. (1983) Physiology of Ticks. Pergamon Press, Oxford and New York, pp. 43-70
- Loew, J., Radda, A., Pretzmann, B., Studynka, G. (1964) Untersuchungen in einem Naturherd der Frühsommer-Meningo-Encephalitis (FSME) in Niederösterreich. Zentralbl. Bakteriol., I. Orig. 194: pp. 133-146
- Levine, J.F., Wilson, M.L., Spielman, A. (1985) A mouse reservoir of the Lyme disease spirochete. Am. J. Trop. Med. Hyg. 34: pp. 355-360
- Milne, A. (1947) The ecology of the sheep tick,Ixodes ricinus L. The infestation of hill sheep. Parasitology 38: pp. 34-50
- Nass, W. (1975) Untersuchungen zur Aktivität der ZeckeIxodes ricinus L. in zwei Naherholungsgebieten der Stadt Halle. Hercynia N.F., Leipzig 12: pp. 325-340
- Negrobov, V.P., Zjuzin, V.S., Borodin, V.S., Alekseenko, N.D. (1965) Zur Ökologie vonIxodes ricinus in den Herdgebieten von Neurovirusinfektionen des Menschen auf dem Territorium der Deutschen Demokratischen Republik. Angew. Parasitol. 6: pp. 34-44
- Ribeiro, J.M.C., Makoul, G.T., Levine, J.F., Robinson, D.R., Spielman, A. (1985) Antihemostatic antiinflammatory, and immunsuppressive properties of the saliva of a tick,Ixodes dammini. J. Exp. Med. 161: pp. 332-344
- Rosicky, B., Cerny, V. (1954) Small Central-European mammals as hosts of the tickIxodes ricinus L.. Zool. Entomol. News 3: pp. 37-46
- Spielman, A., Rossignol, P.A. Insect vectors. In: Warren, K.S., Mahmound, A.A.F. eds. (1984) Tropical and Geographic Medicine. McGraw-Hill, New York, pp. 167-183
- Spielman, A., Clifford, C.M., Piesman, J., Corwin, M.D. (1979) Human babesiosis on Nantucket Island, U.S.A.: description of vector,Ixodes (Ixodes) dammini, n. sp. (Acarina: Ixodidae). J. Med. Entomol. 15: pp. 218-234
- Spielman, A., Wilson, M.L., Levine, J.F., Piesman, J. (1985) Ecology ofIxodes dammini-borne human babesiosis and Lyme disease. Annu. Rev. Entomol. 30: pp. 439-460
- Steere, A.C., Malawista, S.E., Hardin, J.A., Ruddy, S., Askenase, P.W., Andiman, W.A. (1977) Erythema chronicum migrans and Lyme arthritis; the enlarging clinical spectrum. Ann. Intern. Med. 86: pp. 685-698
- Steere, A.C., 1985. Summary. Second International Symposium on Lyme Disease and Related Disorders. Vienna, September 17–19.
- Walter, G., Liebisch, A. (1980) Untersuchungen zur Biologie und Verbreitung von Zecken (Ixodoidea, Ixodidae) in Norddeutschland. III.Ixodes ricinus (Linnaeus 1758). Z. Angew. Zool. 67: pp. 449-476
- Wilson, M.L., Spielman, A. (1985) Seasonal activity of immatureIxodes dammini (Acari: Ixodidae). J. Med. Entomol. 22: pp. 408-414
- Wilson, M.L., Levine, J.F., Spielman, A. (1984) Effect of deer reduction on abundance of the deer tick (Ixodes dammini). Yale J. Biol. Med. 57: pp. 697-705
- Wilson, M.L., Adler, G.H. and Spielman, A., 1985. Correlation between abundance of deer and that of the deer tick,Ixodes dammini (Acari: Ixodidae). Ann. Entomol. Soc. Am., 172–176.
- Wilson, M.L., Piesman, J. and Spielman, A. Abundance ofIxodes dammini reduced through deer removal. in prep., a
- Wilson, M.L., DeRosa, M.J., Levine, J.F. and Spielman, A., Transport of the deer tick,Ixodes dammini (Acari: Ixodidae) by fall migrating birds. in prep., b
- The emergence of Lyme disease in a changing environment in North America and Central Europe
Experimental & Applied Acarology
Volume 2, Issue 4 , pp 337-353
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- 1. Institut für Angewandte Zoologie, Freie Universität Berlin, Haderslebener Strasse 9, 1000, Berlin 41, (Federal Republic of Germany)
- 2. Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, 02115, Boston, MA, (U.S.A.)