Regular Papers

Brain Topography

, Volume 8, Issue 3, pp 285-289

First online:

An event-related potential study on the impairment of automatic processing of auditory input in schizophrenia

  • Yoshikazu ShutaraAffiliated withDepartment of Neuropsychiatry, Kyorin University School of Medicine
  • , Yoshihiko KogaAffiliated withDepartment of Neuropsychiatry, Kyorin University School of Medicine
  • , Kenichi FujitaAffiliated withDepartment of Neuropsychiatry, Kyorin University School of Medicine
  • , Hiroto TakeuchiAffiliated withDepartment of Neuropsychiatry, Kyorin University School of Medicine
  • , Masahiko MochidaAffiliated withDepartment of Neuropsychiatry, Kyorin University School of Medicine
  • , Kenichi TakemasaAffiliated withDepartment of Neuropsychiatry, Kyorin University School of Medicine

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Summary

Mismatch negativity (MMN) and P300 to auditory stimuli was carried out using global field power (GFP) in 25 schizophrenics and 25 normal controls. The peak latencies of MMN and P300 were significantly longer in schizophrenics than in normal controls, and the differences in MMN were marked in the frontal regions. The peak amplitudes of MMN and P300 were significantly smaller in schizophrenics. The scalp distribution of MMN to 1050 Hz tone differed between the two groups, although that to 1100 Hz was similar to each other. The results indicate an impairment in the automatic discrimination process of auditory input in schizophrenics.

Key words

Event-related potential (ERP) Schizophrenia Auditory input P300 Mismatch negativity (MMN) Brief Psychiatric Rating Scale (BPRS)