Cognitive Therapy and Research

, Volume 16, Issue 4, pp 485–502

Cognitive theories of vulnerability to depression: Reconciling negative evidence

  • Jacqueline B. Persons
  • Jeanne Miranda

DOI: 10.1007/BF01183170

Cite this article as:
Persons, J.B. & Miranda, J. Cogn Ther Res (1992) 16: 485. doi:10.1007/BF01183170


Cognitive theories of depression propose that stable beliefs predispose vulnerable individuals to depression. Empirical evidence appears to contradict the stability hypothesis; the cognitions described by the theories appear to covary with depressive symptoms. As a result of these findings, many investigators have concluded that the etiological portions of the cognitive theories are incorrect. We propose an alternative account of the empirical evidence that is consistent with the theories. We propose that the beliefs that are vulnerability factors for depression are stable, but they are accessible only during negative mood states; we call this the mood-state hypothesis. This article describes the mood-state hypothesis, reviews evidence supporting it, and outlines its implications for the cognitive theories of depression. We also describe implications of the mood-state hypothesis for other theories of depression, including biological theories, for studies of psychotherapy process, for studies of other psychopathologies, for epidemiological studies of depression, for the prevention and treatment of depression, and for theories of cognition.

Key words

cognitive theories of depressionvulnerability factorsmood-state hypothesisprevention

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Jacqueline B. Persons
    • 1
  • Jeanne Miranda
    • 1
  1. 1.University of CaliforniaSan FranciscoUSA
  2. 2.OaklandUSA