Neuroscience and Behavioral Physiology

, Volume 23, Issue 5, pp 435–438

The influence of exogenous gangliosides on the dynamics of the development of prolonged posttetanic potentiation

  • N. V. Egorushkina
  • A. S. Ratushnyak
  • I. V. Egorushkin
Article

DOI: 10.1007/BF01183004

Cite this article as:
Egorushkina, N.V., Ratushnyak, A.S. & Egorushkin, I.V. Neurosci Behav Physiol (1993) 23: 435. doi:10.1007/BF01183004

Abstract

The influence of various gangliosides on the dynamics of the development of prolonged posttetanic potentiation (PPTP) in the layer of pyramidal cells of field CA3 during the stimulation of mossy fibers was investigated in rat hippocampus section. It was demonstrated that the GM1 and GD1b gangliosides stimulate the induction and maintenance of PPTP to varying degrees and that GDI a and GTlb inhibit the phase of maintenance as compared with the active control. A conclusion was reached regarding the participation of gangliosides in the mechanisms of synoptic plasticity.

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • N. V. Egorushkina
    • 1
  • A. S. Ratushnyak
    • 1
  • I. V. Egorushkin
    • 1
  1. 1.Institute of Computer TechnologySiberian Division of the Russian Academy of SciencesNovosibirsk