Journal of Neurocytology

, Volume 6, Issue 1, pp 71–84

Quaking mouse: an ultrastructural study of the peripheral nerves

  • Kinuko Suzuki
  • Joy C. Zagoren
Article

DOI: 10.1007/BF01175415

Cite this article as:
Suzuki, K. & Zagoren, J.C. J Neurocytol (1977) 6: 71. doi:10.1007/BF01175415

Summary

Ultrastructural study of the peripheral nervous system of quaking mice has revealed several unusual features in the pattern of myelination in addition to hypomyelination.

These are 1) the presence of ‘atypical’ Schmidt-Lanterman incisures, 2) irregularities of the nodal and internodal termination of Schwann cell cytoplasm and 3) the presence of nonmyelinated segments without associated Schwann cell processes, but covered by basal lamina.

In view of the observation of similar features during the development of the P.N.S. and also during P.N.S. remyelination, we suggest that these features are the results of modified myelination due to a defect in the control mechanisms necessary for normal myelination.

Copyright information

© Chapman and Hall Ltd. 1977

Authors and Affiliations

  • Kinuko Suzuki
    • 1
  • Joy C. Zagoren
    • 1
  1. 1.Departments of Pathology (Neuropathology) and Neuroscience, and the Rose F. Kennedy Center for Research in Mental Retardation and Human DevelopmentAlbert Einstein College of Medicinethe BronxUSA