, Volume 16, Issue 4, pp 285-289

Nuclease sensitivity and methylation of liver chromatin DNA in rats in initial period of effect of glucocorticoids

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Conclusions

  1. Sensitivity of chromatin DNA of rat liver to DNase I and the level of its methylation do not change noticeably 3.5 h after administration of an inducing dose of hydrocortisone to animals.

  2. Loci activated by glucocorticoids must initially possess potentially active conformation sensitive to DNase I.

We express our gratitude to Prof. V. B. Rozen for his interest in the work and useful comments and to V. V. Ashapkin for his assistance in conducting the individual experiments.
Translated from Problemy Éndokrinologii, Vol. 30, No. 6, pp. 38–42, November–December, 1984.