Neuroscience and Behavioral Physiology

, Volume 16, Issue 4, pp 285–289

Nuclease sensitivity and methylation of liver chromatin DNA in rats in initial period of effect of glucocorticoids

  • G. A. Romanov
  • E. N. Zhavoronkova
  • S. V. Savel'ev
  • B. F. Vanyushin
Article

DOI: 10.1007/BF01148168

Cite this article as:
Romanov, G.A., Zhavoronkova, E.N., Savel'ev, S.V. et al. Neurosci Behav Physiol (1986) 16: 285. doi:10.1007/BF01148168

Conclusions

  1. 1.

    Sensitivity of chromatin DNA of rat liver to DNase I and the level of its methylation do not change noticeably 3.5 h after administration of an inducing dose of hydrocortisone to animals.

     
  2. 2.

    Loci activated by glucocorticoids must initially possess potentially active conformation sensitive to DNase I.

     

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • G. A. Romanov
    • 1
  • E. N. Zhavoronkova
    • 1
  • S. V. Savel'ev
    • 1
  • B. F. Vanyushin
    • 1
  1. 1.A. N. Belozerskii Interdepartmental Laboratory of Molecular Biology and Bioorganic ChemistryMoscow State UniversityMoscow