Brain Topography

, Volume 1, Issue 3, pp 183–191

Waves earlier than P3 are more informative in putative subcortical Dementias: A study with mapping and neuropsychological techniques

Authors

  • Narayan P. Verma
    • Wayne State University School of Medicine
  • Cynthia D. Nichols
    • Wayne State University School of Medicine
  • Manfred F. Greiffenstein
    • Wayne State University School of Medicine
    • EEG, EP and Brainmapping LabVAMC-127, Allen Park
  • Rajinder P. Singh
    • Wayne State University School of Medicine
    • EEG, EP and Brainmapping LabVAMC-127, Allen Park
  • Deborah Hurst-Gordon
    • Wayne State University School of Medicine
Article

DOI: 10.1007/BF01129581

Cite this article as:
Verma, N.P., Nichols, C.D., Greiffenstein, M.F. et al. Brain Topogr (1989) 1: 183. doi:10.1007/BF01129581

Summary

Thirty subjects (normal controls, patients with putative subcortical dementia and non-demented patient controls) were studied using advanced neurophysiological (16 scalp-electrode positions, computer-assisted brain electrical activity mapping, auditory oddball paradigm) and neuropsychological techniques. Our study suggests that waves earlier than P3 (N1, P2 and N2) are all correlated with global measures of cognitive functions. They are, however, differentially correlated with specific measures of cognitive functions, N1 and P2 with mental speed and N2 with short-term memory. The abnormalities of these waves (earlier than P3) may be an electrophysiologic marker of dementia in patients with putative subcortical states.

Key words

P300dementiareaction timecognition disordersevoked potentialsbrainmappingevent-related potentials
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Copyright information

© Human Sciences Press, Inc 1989