Journal of Pharmacokinetics and Biopharmaceutics

, Volume 4, Issue 2, pp 183–195

Pharmacokinetics of dosing regimens which utilize multiple intravenous infusions: Gentamicin in burn patients

Authors

  • Ronald J. Sawchuk
    • Clinical Pharmacokinetics Laboratory, College of PharmacyUniversity of Minnesota
  • Darwin E. Zaske
    • Clinical Pharmacokinetics Laboratory, College of PharmacyUniversity of Minnesota
    • St. Paul-Ramsey Hospital and Medical Center
Article

DOI: 10.1007/BF01086153

Cite this article as:
Sawchuk, R.J. & Zaske, D.E. Journal of Pharmacokinetics and Biopharmaceutics (1976) 4: 183. doi:10.1007/BF01086153

Abstract

A general approach to the establishment of dosing regimens for drug administration by multiple intravenous infusions is presented. The method is applicable where the elimination kinetics are first order and can be represented by a one-compartment open model. The approach utilizes serum concentration-time data obtained during any dosing interval for the calculation of the apparent distribution volume and the half-life in individual patients. These values are then used to individualize the dosing regimen where it is required to maintain serum concentrations of the drug within a desired range. Estimation of kinetic parameters for gentamicin in burn patients with normal or only slightly reduced renal function demonstrates a relatively constant distribution volume of 0.25 ± 0.086 liter/kg (mean ±sd)but a relatively variable half-life of 2.1 ± 1.3 hr. This finding supports the view that gentamicin regimens should be individualized even in patients with essentially normal renal function.

Key words

dosage regimensmultiple infusionsmaximum and minimum serum concentrationsgentamicin kinetics in burn patients

Copyright information

© Plenum Publishing Corporation 1976