, Volume 18, Issue 6, pp 455-459

Bile acid secretion and biliary bile acid composition altered by cholecystectomy

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Abstract

After cholecystectomy, bile secretion is continuous and 24-hour bile acid output exceeds that in health. Cholecystokinin-pancreozymin (CCK-PZ) influences neither bile acid secretion nor the bile acid composition of bile after the operation. It is proposed that the absence of the gallbladder causes more rapid enterohepatic recycling of bile acids and therefore increased bile acid secretion. The bile acid composition of bile following cholecystectomy is abnormal for the same reasons. A high proportion of secondary bile acids is present, including several found to be keto bile acids, and this is attributed to increased exposure of the bile acid pool to degradation by intestinal microorganisms.

Presented in part at the Annual Meeting of the American Association for the Study of Liver Diseases, Chicago, 1972.
Supported in part by Research Grant AM-6908 from the National Institutes of Health, Bethesda, Maryland.