The American Journal of Digestive Diseases

, Volume 18, Issue 6, pp 455–459

Bile acid secretion and biliary bile acid composition altered by cholecystectomy

  • Juan R. Malagelada
  • Vay Liang W. Go
  • William H. J. Summerskill
  • Willard S. Gamble
Original Articles

DOI: 10.1007/BF01076595

Cite this article as:
Malagelada, J.R., Go, V.L.W., Summerskill, W.H.J. et al. Digest Dis Sci (1973) 18: 455. doi:10.1007/BF01076595

Abstract

After cholecystectomy, bile secretion is continuous and 24-hour bile acid output exceeds that in health. Cholecystokinin-pancreozymin (CCK-PZ) influences neither bile acid secretion nor the bile acid composition of bile after the operation. It is proposed that the absence of the gallbladder causes more rapid enterohepatic recycling of bile acids and therefore increased bile acid secretion. The bile acid composition of bile following cholecystectomy is abnormal for the same reasons. A high proportion of secondary bile acids is present, including several found to be keto bile acids, and this is attributed to increased exposure of the bile acid pool to degradation by intestinal microorganisms.

Copyright information

© Medical Department Harper & Row, Publishers, Inc. 1973

Authors and Affiliations

  • Juan R. Malagelada
    • 1
    • 2
  • Vay Liang W. Go
    • 1
    • 2
  • William H. J. Summerskill
    • 1
    • 2
  • Willard S. Gamble
    • 1
    • 2
  1. 1.Gastroenterology UnitMayo ClinicRochester
  2. 2.Mayo FoundationRochester