, Volume 149-150, Issue 1, pp 217-222

Membrane phospholipids and adrenergic receptor function

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We have reviewed the effects on adrenergic receptors by membrane phospholipid alterations secondary to oxidative stress and phospholipases' activity. Experimental evidences indicate that the function of both α- and β-adrenoceptors is regulated by their phospholipid microdomain; however, the underlying mechanism is still undefined. No information seems to be available on the influence of phospholipids on β2-adrenoceptors and on all adrenoceptors' subtypes. Thus, further studies are necessary to clarify the role of membrane phospholipids in regulating the function of each member of the adrenergic receptor superfamily.