The American Journal of Digestive Diseases

, Volume 23, Issue 10, pp 929–935

Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs

Authors

  • Zen Itoh
    • G.I. Laboratories, Department of SurgeryGunma University School of Medicine
    • Third Division, Department of Internal MedicineKobe University School of Medicine
    • Laboratory of Bio-organic ChemistryShizuoka College of Pharmaceutical Science
  • Shinjin Takeuchi
    • G.I. Laboratories, Department of SurgeryGunma University School of Medicine
    • Third Division, Department of Internal MedicineKobe University School of Medicine
    • Laboratory of Bio-organic ChemistryShizuoka College of Pharmaceutical Science
  • Isamu Aizawa
    • G.I. Laboratories, Department of SurgeryGunma University School of Medicine
    • Third Division, Department of Internal MedicineKobe University School of Medicine
    • Laboratory of Bio-organic ChemistryShizuoka College of Pharmaceutical Science
  • Kohzaburo Mori
    • G.I. Laboratories, Department of SurgeryGunma University School of Medicine
    • Third Division, Department of Internal MedicineKobe University School of Medicine
    • Laboratory of Bio-organic ChemistryShizuoka College of Pharmaceutical Science
  • Tomohiko Taminato
    • G.I. Laboratories, Department of SurgeryGunma University School of Medicine
    • Third Division, Department of Internal MedicineKobe University School of Medicine
    • Laboratory of Bio-organic ChemistryShizuoka College of Pharmaceutical Science
  • Yutaka Seino
    • G.I. Laboratories, Department of SurgeryGunma University School of Medicine
    • Third Division, Department of Internal MedicineKobe University School of Medicine
    • Laboratory of Bio-organic ChemistryShizuoka College of Pharmaceutical Science
  • Hiroo Imura
    • G.I. Laboratories, Department of SurgeryGunma University School of Medicine
    • Third Division, Department of Internal MedicineKobe University School of Medicine
    • Laboratory of Bio-organic ChemistryShizuoka College of Pharmaceutical Science
  • Noboru Yanaihara
    • G.I. Laboratories, Department of SurgeryGunma University School of Medicine
    • Third Division, Department of Internal MedicineKobe University School of Medicine
    • Laboratory of Bio-organic ChemistryShizuoka College of Pharmaceutical Science
Original Articles

DOI: 10.1007/BF01072469

Cite this article as:
Itoh, Z., Takeuchi, S., Aizawa, I. et al. Digest Dis Sci (1978) 23: 929. doi:10.1007/BF01072469

Abstract

Simultaneous measurement of plasma motilin concentration and gastrointestinal contractile activity was made in 12 healthy dogs. Plasma motilin concentration was measured by radioimmunoassay and gastrointestinal contractile activity was monitored by means of chronically implanted force transducers. During the interdigestive state, it was found that the plasma motilin concentration increased in complete accordance with the cyclical interdigestive contractions of the stomach. Furthermore, plasma motilin concentration was lowered by the ingestion of food, and it remained low as long as the gastric motor activity was in the digestive pattern. Since, as reported previously, the interdigestive contractions can be induced by the exogenous administration of motilin, we concluded that (1) motilin is released at constant intervals during the interdigestive state, and this release is suppressed by the ingestion of food; (2) motilin induces the interdigestive contractions of the stomach and duodenum; and (3) motilin is an interdigestive hormone and is the only known polypeptide hormone of the gut whose release is not induced by a meal.

Copyright information

© Digestive Disease Systems, Inc. 1978