Testing genetic models for multiple symptoms: An application to the genetic analysis of liability to depression
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A model is presented which allows for the contribution of genes and environment to categorical data on multiple symptoms. The model distinguishes between parameters needed to express the relationship between a latent trait and observed responses and the parameters required to represent the causes of variation in the latent trait. The regression of the latent trait on covariates may also be specified. The model is applied to symptoms of depression in 1983 pairs of adult female monozygotic and dizygotic twins. A model which allows only for polygenic variation in the latent trait is supported as well as the “mixed model,” which also allows for the effects of a major gene. The likelihood is significantly lower when all genetic effects are ascribed to a single gene. Practical limitations of the method are discussed.
- Bedford, A., Foulds, G. A., and Sheffield, B. B. (1976). A new personal disturbance scale (DSSI/SAD).Br. J. Soc. Clin. Psychol. 15:387–394.
- Bock, R. D., and Aitkin, M. (1981). Marginal maximum-likelihood estimation of item parameters: Application of an EM algorithm.Psychometrika 46:443–459.
- Bock, R. D., and Lieberman, M. (1970). Fitting a response model forn dichotomously scored items.Psychometrika 35:179–197.
- Cloninger, C. R., Martin, R. L., Guze, S. B., and Clayton, P. J. (1985). Diagnosis and prognosis in schizophrenia.Arch. Gen. Psychiat. 42:15–25.
- Eaves, L. J. (1983). Errors of inference in the detection of major gene effects on psychological test scores.Am. J. Hum. Genet. 35:1179–1189.
- Eaves, L. J. (1984). The resolution of genotype x environment interaction in segregation analysis of nuclear families.Genet. Epidemiol. 1:215–228.
- Eysenck, H. J. (1952).The Scientific Study of Personality, Routledge and Kegan Paul, London.
- Jardine, R., Martin, N. G., and Henderson, A. S. (1984). Genetic covariation between neuroticism and the symptoms of anxiety and depression.Genet. Epidemiol. 1:89–107.
- Kendler, K. S., Heath, A. C., Martin, N. G., and Eaves, L. J. (1986). Symptoms of anxiety and depression in a volunteer twin population: The etiologic role of genetic and environmental factors.Arch. Gen. Psychiat. 43:213–221.
- Kendler, K. S., Heath, A. C., Martin, N. G., and Eaves, L. J. (1987). Anxiety and depression: Same genes, different environments?.Arch. Gen. Psychiat. 44:451–457.
- Lalouel, J. M., Rao, D. C., Morton, N. E., and Elston, R. C. (1983). A unified model for complex segregation analysis.Am. J. Hum. Genet. 35:816–826.
- Lord, F. M., and Novick, M. R. (1968).Statistical Theories of Mental Test Scores, Addison-Wesley, Reading, Mass.
- Mislevy, R. J. (1984). Estimating latent distributions.Psychometrika 49:359–381.
- Numerical Algorithms Group (1982).FORTRAN Subroutine Library, Mark 9, NAG, Oxford.
- Testing genetic models for multiple symptoms: An application to the genetic analysis of liability to depression
Volume 17, Issue 4 , pp 331-341
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- Kluwer Academic Publishers-Plenum Publishers
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- latent trait
- mixed model
- major gene