Behavior Genetics

, Volume 23, Issue 2, pp 163–170

Selective breeding for alcohol preference and associated responses

  • Ting-Kai Li
  • Lawrence Lumeng
  • Donald P. Doolittle

DOI: 10.1007/BF01067421

Cite this article as:
Li, TK., Lumeng, L. & Doolittle, D.P. Behav Genet (1993) 23: 163. doi:10.1007/BF01067421


Selective breedng for high and low alcohol-drinking preference has produced rat lines useful for studying the nature of excessive alcohol-seeking behavior. Compared with the alcohol-nonpreferring line, the preferring animals exhibit heightened responsivity to the low-dose activating effects of ethanol as well as enhanced capacity for developing tolerance to the aversive, behaviorally impairing effects of ethanol. The preferring animals exhibit lower brain serotonin and dopamine neurotransmitter activity as well as differences in other neurotransmitter neuromodulator systems, compared with the alcoholnonpreferring animals.

Key Words

Alcohol self-administrationethanol reinforcementtoleranceserotonindopamine

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Ting-Kai Li
    • 1
  • Lawrence Lumeng
    • 1
    • 2
  • Donald P. Doolittle
    • 3
  1. 1.Department of MedicineIndiana University School of MedicineIndianapolis
  2. 2.VAMCIndianapolis
  3. 3.The Jackson LaboratoryBar Harbor