Preabsorptive vs. postabsorptive control of ethanol intake in C57BL/6J and DBA/2J mice
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Experimentally naive male mice of both strains were exposed to a two-bottle choice situation (ethanol vs. water) and their drinking behavior was observed during the first hour. DBA/2J mice developed a significant avoidance of 2% or 10% ethanol during the first 10 min. At 15 and 60 min following introduction of the bottles, no DBA mouse exhibited more than a 6 mg % blood ethanol level while all of the C57BL mice exceeded this concentration. Significant postabsorptive effects in the DBA mice seem unlikely at these very low blood ethanol values. Animals of both strains were examined for their ability to form lithium-induced conditioned taste aversions to 2% ethanol or 15% sucrose solutions. DBA mice readily formed conditioned aversions to both solutions, but the C57BL strain significantly avoided only the sucrose. C57BL mice appear to have difficulty in discriminating the 2% ethanol from distilled water. The neural sensitivity to ethanol was examined in both strains using the sleep time test and the grid test. C57BL mice were significantly more sensitive than DBA mice in both tests.
- Belknap, J. K. (1975). The grid test: A measure of alcohol- and barbiturate-induced behavioral impairment in mice.Behav. Res. Methods Instrum. 7:66–67.
- Belknap, J., MacInnes, J., and McClearn, G. (1972). Ethanol sleep times and hepatic alcohol and aldehyde dehydrogenase activities in mice.Physiol. Behav. 9:453–457.
- Damjanovich, R., and MacInnes, J. (1973). Factors involved in ethanol narcosis: Analysis in mice of three inbred strains.Life Sci. 13:55–65.
- Fuller, J. L. (1964). Measurement of alcohol preference in genetic experiments.J. Comp. Physiol. Psychol. 57:85–88.
- Fuller, J. L. (1967). Effect of drinking schedule upon alcohol preference in mice.Q. J. Stud. Alcohol 28:22–26.
- Horowitz, G., and Whitney, G. (1975). Alcohol-induced conditioned aversion: Genotypic specificity in mice (Mus musculus).J. Comp. Physiol. Psychol. 89:340–346.
- Kakihana, R., Brown, D., McClearn, G. E., and Tabershaw, I. (1966). Brain sensitivity to alcohol in inbred mouse strains.Science 154:1574–1575.
- LeMagnen, J. (1972). Alcohol consumption in normal and hyperphagic rats: Orosensory and metabolic factors. In Forsander, O., and Eriksson, K. (eds.),Biological Aspects of Alcohol Consumption, Rutgers University Press, New Brunswick, N.J.
- Lin, D. C. (1975). Brain and blood levels of ethanol and acetaldehyde in strains of mice with different preferences for ethanol.Chem. Pathol. Pharmacol., 365–371.
- McClearn, G. E. (1968). Genetics and motivation in the mouse. InNebraska Symposium on Motivation, Lincoln, Nebr.
- McClearn, G. E., and Nichols, D. (1970). Effects of intraperitoneal injection of ethanol on ethanol ingestion of C57BL mice.Psychon. Sci. 20:55–56.
- Mirone, L. (1957). Dietary deficiency in mice in relation to voluntary alcohol consumption.Q. J. Stud. Alcohol 18:552–560.
- Nachman, M., LaRue, C., and LeMagnen, J. (1971). The role of olfactory and orosensory factors in the alcohol preference of inbred strains of mice.Physiol. Behav. 6:53–59.
- Rodgers, D. A. (1967). Alcohol preference in mice. In Zubin, J., and Hunt, H. (eds.),Comparative Psychopathology, Grune and Stratton, New York.
- Rodgers, D. (1972). Factors underlying differences in alcohol preference in inbred strains of mice. In Kissin, B., and Begleiter, H. (eds.),The Biology of Alcoholism, Plenum, New York.
- Rodgers, D. A., and McClearn, G. E. (1962). Alcohol preference of mice. In Bliss, E. (ed.),Roots of Behavior, Hoeber, New York.
- Rodgers, D., McClearn, G., Bennett, E., and Hebert, M. (1963). Alcohol preference as a function of its caloric utility in mice.J. Comp. Physiol. Psychol. 56:666–672.
- Schlesinger, K. (1966). Genetic and biochemical correlates of alcohol preference in mice.Am. J. Psychiat. 122:767–773.
- Schlesinger, K., Kakihana, R., and Bennett, E. (1966). Effects of tetraethylthiuramdisulfide (Antabuse) on the metabolism and consumption of ethanol in mice.Psychosom. Med. 28:514–520.
- Schneider, C. W., Evans, S. K., Chenoweth, M., and Beman, F. (1973). Ethanol preference and behavioral tolerance in mice.J. Comp. Physiol. Psychol. 82:466–474.
- Sheppard, J. R., Albersheim, P., and McClearn, G. E. (1968). Enzyme activities and ethanol preference in mice.Biochem. Genet. 2:205–212.
- Sheppard, J. R., Albersheim, P., and McClearn, G. E. (1970). Aldehyde dehydrogenase and ethanol preference in mice.J. Biol. Chem. 245:2875–2882.
- Thiessen, D. D., Whitworth, N., and Rodgers, D. (1966). Reproductive variables and alcohol consumption of the C57BL/Crgl female mouse.Q. J. Stud. Alcohol 27:591–595.
- Thiessen, D. D., Whitworth, N., and Rodgers, D. (1967). Reproductive functions and metabolic capacity as determinants of alcohol preference in C57BL female mice.J. Comp. Physiol. Psychol. 63:151–154.
- Thomas, K. (1969). Selection and avoidance of alcohol solutions by two strains of inbred mice and derived generations.Q. J. Stud. Alcohol 30:849–861.
- Whitney, G., and Whitney, Y. (1968). Ethanol toxicity in the mouse and its relationship to ethanol selection.Q. J. Stud. Alcohol 29:44–48.
- Wilson, C. W. M. (1972). The limiting factors in alcohol consumption. In Forsander, O., and Eriksson, K. (eds.),Biological Aspects of Alcohol Consumption, Rutgers University Press, New Brunswick, N.J.
- Preabsorptive vs. postabsorptive control of ethanol intake in C57BL/6J and DBA/2J mice
Volume 7, Issue 6 , pp 413-425
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- alcohol (ethanol) preference
- sleep time test
- lithium-induced conditioned aversion
- C57BL and DBA mice