, Volume 2, Issue 1, pp 3-19

The investigation of linkage between a quantitative trait and a marker locus

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Procedures are given, using sib pairs, for estimating linkage between a knownm-allele locus and a hypothesized two-allele locus that governs a quantitative trait. Random mating and linkage equilibrium are assumed. Also given are parametric and nonparametric methods for detecting linkage when the trait in question is governed by several two-allele loci, provided there is no epistasis.

This investigation was supported by a U.S. Public Health Service Training Grant (2 T01 GM00038), Research Career Development Award (1-K3-GM-31,732), and a research grant (GM HD 16697) from the National Institute of General Medical Sciences.