A double-peak phenomenon in the pharmacokinetics of veralipride after oral administration: A double-site model for drug absorption
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- Plusquellec, Y., Campistron, G., Staveris, S. et al. Journal of Pharmacokinetics and Biopharmaceutics (1987) 15: 225. doi:10.1007/BF01066319
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Equal doses of veralipride have been given to 12 healthy volunteers by three different administrations-intravenous infusion, oral solution, and oral capsule-in a randomized cross-over design. After the intake of the solution, but not after infusion or capsules, two maximum plasma concentrations have been observed and interpreted, according to a double-site model for drug absorption.