A double-peak phenomenon in the pharmacokinetics of veralipride after oral administration: A double-site model for drug absorption

  • Yves Plusquellec
  • G. Campistron
  • S. Staveris
  • J. Barre
  • L. Jung
  • J. P. Tillement
  • G. Houin
Introduction

DOI: 10.1007/BF01066319

Cite this article as:
Plusquellec, Y., Campistron, G., Staveris, S. et al. Journal of Pharmacokinetics and Biopharmaceutics (1987) 15: 225. doi:10.1007/BF01066319

Abstract

Equal doses of veralipride have been given to 12 healthy volunteers by three different administrations-intravenous infusion, oral solution, and oral capsule-in a randomized cross-over design. After the intake of the solution, but not after infusion or capsules, two maximum plasma concentrations have been observed and interpreted, according to a double-site model for drug absorption.

Key words

veralipride pharmacokinetics enterohepatic recycling double site of drug absorption 

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Yves Plusquellec
    • 1
  • G. Campistron
    • 2
  • S. Staveris
    • 3
  • J. Barre
    • 4
  • L. Jung
    • 3
  • J. P. Tillement
    • 4
  • G. Houin
    • 2
  1. 1.Biomathématiques, U.E.R. de MathématiquesUniversité Paul SabatierToulouseFrance
  2. 2.Laboratoire de Pharmacologie, Faculté des Sciences PharmaceutiquesUniversité Paul SabatierToulouseFrance
  3. 3.Laboratoire de Pharmacie chimiqueFaculté de PharmacieStrasbourgFrance
  4. 4.Laboratoire de Biochimie 1 et PharmacologieCHI CréteilCréteilFrance