, Volume 16, Issue 6, pp 605-610

Phenylthiocarbamide (PTC) preference among laboratory mice: Understanding of a previously “unreplicated” report

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Abstract

In two-bottle preference tests aversion to phenylthiocarbamide (PTC) develops over a period of days. Thus, as previously reported, following experience with appropriate concentrations of PTC, mice of the BALB inbred strain display an aversion in contrast to C57BL inbred mice. It is suggested that differential learning in a conditioned taste-aversion paradigm might be responsible for the phenotypic strain contrast. The difference in PTC aversion phenotype among mice could be due to differences in any mechanism contributing to differential flavor toxicosis conditioning instead of, or in addition to, strain differences in sensitivity to the sensory attributes of PTC.

This research was supported in part by Grant NS 15560 from the NINCDS.