A new statistical procedure for testing equivalence in two-group comparative bioavailability trials
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The clinical problem of testing for equivalence in comparative bioavailability trials is restated in terms of the proper statistical hypotheses. A simple t-test procedure for these hypotheses has been devloped that is more powerful than the methods based on usual (shortest) and symmetric confidence intervals. In this note, this new procedure is explained and an example is given, including the method for sample size determination.
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- A new statistical procedure for testing equivalence in two-group comparative bioavailability trials
Journal of Pharmacokinetics and Biopharmaceutics
Volume 12, Issue 1 , pp 83-91
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- Kluwer Academic Publishers-Plenum Publishers
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- hypothesis tests
- sample size determination
- Industry Sectors
- Author Affiliations
- 1. Northwestern University Cancer Center and Department of Community Health and Preventive Medicine, Northwestern University Medical School, Chicago, Ill.
- 3. American Critical Care, McGaw Park, Ill.
- 4. Department of Epidemiology and Biometry, University of Illinois, School of Public Health, Chicago, Ill.