Time-dependent variations in the organ extraction ratios of acetaminophen in rat

  • Pierre M. Bélanger
  • Marcel Lalande
  • François Doré
  • Gaston Labrecque
Article

DOI: 10.1007/BF01062340

Cite this article as:
Bélanger, P.M., Lalande, M., Doré, F. et al. Journal of Pharmacokinetics and Biopharmaceutics (1987) 15: 133. doi:10.1007/BF01062340

Abstract

The pharmacokinetics of a single 40mg/kg dose of acetaminophen was investigated at 09h00 and 21h00 in Sprague-Dawley rats synchronized to a 12-h light-dark cycle. Acetaminophen was administered by the intraarterial, intravenous, intraperitoneal, and oral routes in order to determine the contribution of the gastrointestinal tract, liver, and lung to the oral extraction ratio of the drug. A mean oral extraction ratio of 0.46 was obtained at 21h00 as compared to 0.39 at 09h00. The mean extraction ratios of the gastrointestine, liver, and lung were 0.05, 0.41, and 0 at 09h00 and 0.18, 0.24, and 0.13 at 21h00, respectively. These results indicate that the extrahepatic metabolism of acetaminophen is important at 21h00, but is barely detectable at 09h00, whereas the hepatic extraction ratio is higher at 09h00 than at 21h00. Thus, there are temporal variations in the disposition of acetaminophen in the rat.

Key words

Acetaminophen kinetics temporal variations diurnal variations extrahepatic metabolism extraction ratio chronopharmacokinetics 

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Pierre M. Bélanger
    • 1
  • Marcel Lalande
    • 1
  • François Doré
    • 2
  • Gaston Labrecque
    • 1
  1. 1.Ecole de PharmacieUniversité LavalSte-FoyCanada
  2. 2.Département de PharmacologieUniversité LavalSte-FoyCanada