Journal of Pharmacokinetics and Biopharmaceutics

, Volume 16, Issue 3, pp 303–309

Testing for the equality of area under the curves when using destructive measurement techniques


  • A. John Bailer
    • Division of Biometry and Risk AssessmentNational Institute of Environmental Health Sciences

DOI: 10.1007/BF01062139

Cite this article as:
Bailer, A.J. Journal of Pharmacokinetics and Biopharmaceutics (1988) 16: 303. doi:10.1007/BF01062139


The area under a curve (AUC) of metabolite concentration or drug concentration over time has biological meaning in many situations, and the test of AUC equality among a set of different dosing regimens is often of interest. For the situation where the experimental unit must be sacrificed in order to obtain an estimate of the metabolite or drug concentration, it is noted that linear combinations of mean concentrations at time points for a particular dosing regimen can be used to estimate the AUC for that regimen. Contrasts among AUC estimates are readily constructed and tested within this derivation.

Key words

area under the curvecontrastsdestructive sampling

Copyright information

© Plenum Publishing Corporation 1988