Journal of Pharmacokinetics and Biopharmaceutics

, Volume 6, Issue 6, pp 547–558

Statistical moments in pharmacokinetics

  • Kiyoshi Yamaoka
  • Terumichi Nakagawa
  • Toyozo Uno
Article

DOI: 10.1007/BF01062109

Cite this article as:
Yamaoka, K., Nakagawa, T. & Uno, T. Journal of Pharmacokinetics and Biopharmaceutics (1978) 6: 547. doi:10.1007/BF01062109

Abstract

Statistical moments are parameters that describe the characteristics of the time courses of plasma concentration (area, mean residence time, and variance of residence time) and of the urinary excretion rate that follow administration of a single dose of a drug. The relationship between the moments of a time-course curve and pharmacokinetic profiles of drug disposition, i.e., absorption, distribution, metabolism, and excretion, is described. The moments are related to the extent and rate of bioavailability, and it is shown that they can be effectively applied to the deconvolution operation.

Key words

statistical momentsnetwork theorypharmacokineticsbioavailabilitydeconvolutionplasma concentration-time curveurinary excretion rate-time curvecompartment models

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Kiyoshi Yamaoka
    • 1
  • Terumichi Nakagawa
    • 1
  • Toyozo Uno
    • 1
  1. 1.Faculty of Pharmaceutical SciencesKyoto UniversityKyotoJapan