European Journal of Clinical Pharmacology

, Volume 34, Issue 1, pp 77–82

Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

  • B. Olsson
  • M. Johansson
  • J. Gabrielsson
  • P. Bolme
Originals

DOI: 10.1007/BF01061422

Cite this article as:
Olsson, B., Johansson, M., Gabrielsson, J. et al. Eur J Clin Pharmacol (1988) 34: 77. doi:10.1007/BF01061422

Summary

The pharmacokinetics and bioavailability of N-acetylcysteine (NAC) have been determined after its intravenous and oral administration to 6 healthy volunteers.

According to a randomized cross-over design each subject received NAC 200 mg i.v. and 400 mg p.o., and blood samples were collected for 30 h.

Reduced NAC had a volume of distribution (VSS) of 0.59 l·kg−1 and a plasma clearance of 0.84 l·h−1·kg−1. The terminal half-life after intravenous administration was 1.95 h. The oral bioavailability was 4.0%.

Based on total NAC concentration, its volume of distribution (VSS) was 0.47 l·kg−1 and its plasma clearance was 0.11 l·h−1·kg−1. The terminal half-life was 5.58 h after intravenous administration and 6.25 h after oral administration. Oral bioavailability of total NAC was 9.1%.

Key words

N-acetylcysteinepharmacokineticsbioavailability

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • B. Olsson
    • 1
  • M. Johansson
    • 1
  • J. Gabrielsson
    • 2
  • P. Bolme
    • 3
  1. 1.Research and Development DepartmentACO Läkemedel ABSolnaSweden
  2. 2.Department of Biopharmaceutics and PharmacokineticsUniversity of UppsalaUppsalaSweden
  3. 3.Department of PaediatricsHuddinge HospitalHuddingeSweden