Journal of Pharmacokinetics and Biopharmaceutics

, Volume 3, Issue 6, pp 387–418

Pharmacokinetics in the aged: A review

  • Edward J. Triggs
  • Roger L. Nation

DOI: 10.1007/BF01059473

Cite this article as:
Triggs, E.J. & Nation, R.L. Journal of Pharmacokinetics and Biopharmaceutics (1975) 3: 387. doi:10.1007/BF01059473


Age-related differences in drug response have recently received increased attention in the medical literature. This report reviews those recent publications dealing with the study of pharmacokinetics in the aged population. The rate and extent of drug absorption do not appear to be altered to any appreciable degree in the elderly patient. However, drug disposition in the aged subject may be affected by a number of factors including alterations in protein binding, apparent volumes of distribution, and renal and/or extrarenal clearance of the drug.

Key words

review pharmacokinetics elderly clinical considerations 

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • Edward J. Triggs
    • 1
  • Roger L. Nation
    • 1
  1. 1.Department of PharmacyUniversity of SydneySydneyAustralia

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