Archives of Environmental Contamination and Toxicology

, Volume 15, Issue 1, pp 61–67

Associations between metabolites of aromatic compounds in bile and the occurrence of hepatic lesions in English sole (Parophrys vetulus) from Puget Sound, Washington

  • Margaret M. Krahn
  • Linda D. Rhodes
  • Mark S. Myers
  • Leslie K. Moore
  • William D. MacLeodJr.
  • Donald C. Malins
Article

DOI: 10.1007/BF01055249

Cite this article as:
Krahn, M.M., Rhodes, L.D., Myers, M.S. et al. Arch. Environ. Contam. Toxicol. (1986) 15: 61. doi:10.1007/BF01055249

Abstract

Statistical comparisons were made between the relative mean concentrations of metabolites of aromatic compounds in bile (as estimated by a high-performance liquid chromatography/fluorescence detection method) and idiopathic liver lesions in English sole (Parophrys vetulus) from eleven Puget Sound sites. A significant positive correlation was found between prevalences of neoplasms, foci of cellular alteration, megalocytic hepatosis and total hepatic lesions and the concentrations of metabolites of aromatic compounds. These findings provide further evidence of the putative relationship between aromatic compounds and serious idiopathic liver diseases in bottom-dwelling fish.

Copyright information

© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • Margaret M. Krahn
    • 1
  • Linda D. Rhodes
    • 1
  • Mark S. Myers
    • 1
  • Leslie K. Moore
    • 1
  • William D. MacLeodJr.
    • 1
  • Donald C. Malins
    • 1
  1. 1.Environmental Conservation DivisionNorthwest and Alaska Fisheries CenterSeattle