Humoral immunity in the chicken as affected by mercury
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
An evaluation was made of the effects of chronic and acute mercury (Hg) treatments on humoral immunity in the chicken. Three treatments were examined,i.e., chronic, acute high, and acute low Hg treatments. Although chronic dietary treatment with 300 ppm of Hg in the drinking water was growth inhibitory, acute high and low Hg treatments given by IM injections were not growth inhibitory. Chronically-treated birds showed suppressed primary and secondary responses to challenge with sheep red blood cells (SRBC). Additionally, immunoglobulin M levels were reduced to a greater extent than immunoglobulin G levels in chronically-treated birds. These effects did not occur in birds that received acute high and low Hg treatments. Immune suppression by growth inhibitory Hg treatment agrees with published reports and the differential effect on specific immunoglobulin levels is a new finding. Primary responses toBrucella abortus (BA) in chronically-treated birds were also suppressed, but secondary responses were enhanced. These data further clarify the role of Hg on immune responsiveness in chickens.
- Barr, A. J., J. H. Goodnight, J. P. Sall, and J. T. Helwig: A user's guide to SAS 76. Raleigh: Sparks Press (1976).
- Blakley, B. R., C. S. Sisodia, and T. K. Mukkur: The effects of methylmercury, tetraethyl lead, and sodium arsenate on the humoral immune response in mice. Tox. Appl. Pharmacol.52, 245 (1980).
- Brake, J., P. Thaxton, and P. Y. Hester: Mercury induced cardiovascular abnormalities in the chicken. Arch. Environ. Contam. Tox.6, 269 (1977).
- Bridger, M. A.: The effects of mercury on humoral and cellmediated immunity in the domestic chicken. M. S. Thesis, North Carolina State University, Raleigh, NC (1981).
- Delhanty, J. J., and J. B. Solomon: The nature of the antibodies to goat erythrocytes in the developing chicken. Immunol.11, 103 (1966).
- Hill, C. H.: Dietary influences on resistance toSalmonella infection in chicks. Fed. Proc.38, 2129 (1979).
- —: Influence of time of exposure to high levels of minerals on the susceptibility of chicks toSalmonella gallinarum. J. Nutr.110, 433 (1980).
- Kincade, P. W., and M. D. Cooper: Development and distribution of immunoglobulin-containing cells in the chicken. An immunofluorescent analysis using purified antibodies to mu, gamma, and light chains. J. Immunol.106, 371 (1971).
- Koller, L. D.: Immunosuppression produced by lead, cadmium, and mercury. Am. J. Vet. Res.34, 1451 (1973).
- Koller, L. D., and J. H. Exon: Methylmercury: Effect on serum enzymes and humoral antibody. J. Tox. Environ. Hlth.2, 1115 (1977).
- Kramer, C. Y.: Extension of multiple range tests to group means with unequal numbers of replications. Biometrics,12, 307 (1956).
- McCorkle, F., and B. Glick: The effect of aging on immune competence in the chicken's antibody mediated immunity. Poultry Sci.59, 669 (1980).
- Nriagu, J. O.: The biochemistry of mercury in the environment. N.Y.: Topics in Environ. Hlth., vol. 3 (1979).
- Sapin, C., E. Druet, and P. Druet: Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride. Clin. Exp. Immunol.28, 173 (1977).
- Thaxton, P.: Physiological effects of mercury in the domestic chicken. Barcelona, Spain: Proc. First Int. Mercury Cong. (1974).
- Thaxton, P., and C. R. Parkhurst: Toxicity of mercury in young chickens. 3. Changes in immunological responsiveness. Poultry Sci.52, 761 (1973).
- Witlin, B.: Detection of antibodies by microtitration techniques. Mycopath. et Mycol. Appl.33, 241 (1967).
- Humoral immunity in the chicken as affected by mercury
Archives of Environmental Contamination and Toxicology
Volume 12, Issue 1 , pp 45-49
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors