, Volume 10, Issue 5, pp 561-569

The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas

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The bioconcentration and metabolism of benz(a)acridine in fathead minnows (Pimephales promelas) was investigated using14C-labelled benz(a)acridine. The rates of uptake, elimination, and metabolic transformation of benz(a)acridine were estimated in the fish. The equilibrium concentration factor [ratio of benz(a)acridine concentration in fish (wet weight) to benz(a)acridine concentration in water] was estimated at 106±17. The observed bioconcentration factor was about one tenth of that predicted by octanol-water partitioning models. Metabolic alteration was estimated to reduce the degree of bioconcentration 50 to 90% from the hypothetical case in which metabolic transformation did not occur. Benz(a)acridine metabolites attained concentrations in the fish considerably in excess of benz(a)acridine itself.

Research sponsored by the Office of Health and Environmental Research, U.S. Department of Energy, under contract W-7405-eng-26 with Union Carbide Corp.
Publication No. 1598, Environmental Sciences Division, ORNL.