Abstract
The effects of prolonged fractionated external low-dose X-ray irradiation (total dose of 1–2 Gy), continuous internal irradiation resulting from parenteral injection of137Cs, and combined external and internal irradiation resulting from prolonged maintenance of experimental animals in the zone contaminated after the Chernobyl' catastrophe were studied in albino rats. All the above-mentioned influences are shown to result in an expressed long-lasting intensification of lipid peroxidation (LP). A considerable increase in the levels of secondary LP products and endogenous peroxides in the brain tissue and blood plasma is observed. The state of the glutathione antioxidative system is significantly modified. Administration of a complex of fat-soluble and water-soluble antioxidative drugs to the experimental animals considerably corrected negative effects of prolonged low-intensity irradiation. The mechanisms of functional shifts in the nervous system, resulting from a long-lasting LP activation and an insufficiency of the physiological antioxidative system, and possible approaches for correction of such disorders are discussed.
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References
S. M. Alekhina, L. V. Drobinskaya, and I. G. Khalyavko, “Lipid peroxidation and the antioxidative blood system in persons subjected to the influence of radiation related to the catastrophe of ChNPS,” in:The Congress on Radiobiology, Summaries of Reports [in Russian], Vol. 1, Pushchino (1993), p. 12.
F. S. Torubanov, M. K. Nikolaev, P. V. Chesanov, et al., “The state of the nervous system in persons irradiated at various dose ranges during cleanup of the catastrophe at ChNPS,”Med. Radiologiya 36, No. 5, 17–20 (1991).
I. I. Kut'ko, “An asthenic syndrome and its correction in persons subjected to the influence of radiation because of the ChNPS catastrophe,” in:Proccedings of Conference ‘Chernobyl' and the Health of People’ [in Russian], Part II,Ukrainian National Center of Radiological Medicine Kiev (1993), p. 180.
L. A. Kryzhanovskaya, “On the clinical diagnostics and classification of mental disorders that appeared after the ChNPS catastrophe,” in:Proccedings of Conference ‘Chernobyl' and the Health of People’ [in Russian], Part II,Ukrainian National Center of Radiological Medicine Kiev (1993), p. 175.
V. A. Salamatov, “The mental aspects of stress in the staff of the ChNPS isolation zone,” in:The Congress on Radiobiology, Summaries of Reports [in Russian], Vol. 1, Pushchino (1993), p. 881–882.
V. A. Baraboi and D. A. Sutkovoi, “Indices of the oxidative metabolism in rat brain tissues: effects of acute low-dose X-ray irradiation,”Neirofiziologiya/Neurophysiology 27, No. 2, 93–99 (1995).
V. V. Borisova, T. M. Voevodina, A. V. Fedorova, et al.,Biological Effects Related to the Long-Lasting Penetration of Radionuclides [in Russian], Energoatomizdat, Moscow (1988).
I. D. Stal'naya and G. G. Garishvili,Current Techniques in Biochemistry [in Russian], Meditsina, Moscow (1977).
C. S. Chio and A. H. Tappel, “Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids,”Biochemistry 9, 2821–2827 (1969).
G. O. Kruglikova and Ts. M. Shtutman, “Glutathione peroxidase and glutathione reductase activity in the liver of rats after injections of sodium selenite,”Ukr. Biochim. Zh. 48, No. 2, 223–228 (1976).
A. A. Pokrovskii and A. A. Abrarov, “On the question of peroxidation resistance of erythrocytes,”Lab. Delo, No. 1, 44–49 (1972).
Ya. I. Serkiz, V. G. Pinchuk, L. B. Pinchuk, et al.,Radiobiological Aspects of the Catastrophe at the Chernobyl' NPS [in Russian], Naukova Dumka, Kiev (1992).
E. G. Egorova, “Endogenous phospholipase hydrolysis in radiation-induced impairment of animals,”Radiobiologiya 27, Sect. 1, 97–100 (1982).
I. K. Kolomi'itseva,Radiation Biochemistry of Membrane Lipids [in Russian], Nauka, Moscow (1989).
A. I. Dvoretskii, S. N. Airapetyan, A. M. Shainskaya, and E. E. Chebotarev,Transmembrane Transfer of Ions in Action of Ionizing Radiation on an Organism [in Russian], Naukova Dumka, Kiev (1990).
A. Yu. Sungurov, “Radiobiology of cellular surface,” in:Advances in Science and Technology, Ser. Radiation Biology [in Russian], Vol.7, VINITI, Moscow (1990).
S. T. Ryskulova,Radiation Biology of the Plasma Membranes [in Russian], Energoatomizdat, Moscow (1986).
A. T. Nosov, D. A. Sutkovoi, V. A. Baraboi, and M. I. Shamaev, “Effects of low doses of long-lasting radiation influence on ultrastructure characteristics and intensity of lipid peroxidation in the brain and blood of rats,”Radiobiologiya Radioekologiya 34, No. 4/5, 631–638 (1994).
A. I. Komarnitskii, “Effects of ionizing radiation on bioelectrical activity of the hypothalamic nuclei in adult and old rats,” in:The Congress on Radiobiology, Summaries of Reports [in Russian], Vol. 2, Pushchino (1993).
A. O. Dudkin, S. I. Peimer, and A. G. Sverdlov, “Effects of low doses of ionizing radiation on the functional state of neurons in slices of mammal brain,” in:All-Union Conference on the Effects of Low Doses of Ionizing Radiation [in Russian], Naukova Dumka, Kiev (1984).
S. V. Makarenko, V. I. Voronovskaya, Yu. Ya. Maidikov, and A. B. Sprin', “Higher nervous activity in persons subjected to radiation influences: its state six years after the catastrophe at ChNPS,” in:The Congress on Radiobiology, Summaries of Reports [in Russian], Vol. 3, Pushchino (1993).
Postradiation Encephalopathy [in Russian], A. P. Romodanov (ed.), Ukrainian Institute of Neurosurgery, Kiev (1993).
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Neirofiziologiya/Neurophysiology, Vol. 27, No. 4, pp. 243–252, July–August, 1995.
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Sutkovoi, D.A., Baraboi, V.A. & Oleinik, S.A. Indices of the oxidative metabolism in rat brain tissues: Effects of prolonged low-dose X-ray irradiation. Neurophysiology 27, 193–200 (1995). https://doi.org/10.1007/BF01053333
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DOI: https://doi.org/10.1007/BF01053333