Journal of Neuro-Oncology

, Volume 19, Issue 1, pp 69–74

A phase II study of intravenous carboplatin for the treatment of recurrent gliomas

  • Ronald E. Warnick
  • Michael D. Prados
  • Ellen E. Mack
  • Kym L. Chandler
  • François Doz
  • Jane E. Rabbitt
  • Mary K. Malec
Clinical Study

DOI: 10.1007/BF01051050

Cite this article as:
Warnick, R.E., Prados, M.D., Mack, E.E. et al. J Neuro-Oncol (1994) 19: 69. doi:10.1007/BF01051050
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Summary

Thirty-two patients with recurrent glioma who had previously received radiation therapy and chemotherapy with nitrosoureas were treated with intravenous carboplatin every 3 weeks, starting at a dose of 350 mg/m2, with a dose escalation of 25 mg/m2 every 6 weeks until a level 4 hematologic toxicity was reached. Of the 28 patients who could be evaluated for a response, 50% demonstrated a response or had stabilization of their disease after two infusions of carboplatin. Their median time to tumor progression and median duration of survival were 19 weeks and 38 weeks. Thrombocytopenia was the major toxicity and was severe in one-third of the patients. No neurologic or renal toxicities were noted. Carboplatin has demonstrated activity against recurrent gliomas in patients who have already had extensive chemotherapy. Increasing the dose of carboplatin may improve the rate of response and the duration of progression-free survival in patients with recurrent glioma.

Key words

carboplatin brain tumors recurrent glioma 

Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Ronald E. Warnick
    • 1
  • Michael D. Prados
    • 1
  • Ellen E. Mack
    • 1
  • Kym L. Chandler
    • 1
  • François Doz
    • 1
  • Jane E. Rabbitt
    • 1
  • Mary K. Malec
    • 1
  1. 1.Brain Tumor Research Center of the Department of Neurological SurgerySchool of Medicine, University of CaliforniaSan FranciscoUSA
  2. 2.Department of NeurosurgeryUniversity of CincinnatiCincinnatiUSA
  3. 3.Department of Neurological Surgeryc/o The Editorial OfficeSan FranciscoUSA

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