Glycoconjugate Journal

, Volume 6, Issue 3, pp 349–353

Conserved sequences in bacterial and viral sialidases

  • Peter Roggentin
  • Bernd Rothe
  • James B Kaper
  • James Galen
  • Lois Lawrisuk
  • Eric R Vimr
  • Roland Schauer
Article

DOI: 10.1007/BF01047853

Cite this article as:
Roggentin, P., Rothe, B., Kaper, J.B. et al. Glycoconjugate J (1989) 6: 349. doi:10.1007/BF01047853

Abstract

The genes of the bacterial sialidases fromClostridium sordellii G12,C. perfringens A99,Salmonella typhimurium LT-2 andVibrio cholerae 395 sequenced so far were examined for homologies and were compared with sequences of viral sialidases.

Each of the bacterial sialidases contains a short sequence of twelve amino-acids, which is repeated at four positions in the protein. All these sequences exhibit significant similarities. Comparing the repeated sequences of the four sialidases, five amino-acids were found to be highly conserved at defined positions: Ser-X-Asp-X-Gly-X-Thr-Trp. Additionally, most of the distances betweeen the four repeated regions are also conserved among the different sialidases. The conserved bacterial sequences show similarity with sialidases of influenza A H7N1 and H13N9.

Key words

sialidase sequence homologies Clostridium perfringens C. sordellii Salmonella typhimurium Vibrio cholerae Influenza A virus 

Copyright information

© Glycoconjugate Journal AB 1989

Authors and Affiliations

  • Peter Roggentin
    • 1
  • Bernd Rothe
    • 1
  • James B Kaper
    • 2
  • James Galen
    • 2
  • Lois Lawrisuk
    • 3
  • Eric R Vimr
    • 3
  • Roland Schauer
    • 1
  1. 1.Biochemisches InstitutChristian-Albrechts-UniversitätKielW. Germany
  2. 2.Center for Vaccine Development, Division of Geographic MedicineUniversity of MarylandBaltimoreUSA
  3. 3.Department of Veterinary Pathobiology, Microbiology Division, College of Veterinary MedicineUniversity of Illinois at Urbana-ChampaignUlbanaUSA

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