European Journal of Clinical Pharmacology

, Volume 34, Issue 5, pp 461–464

Intraindividual variability in the relative systemic availability of cyclosporin after oral dosing

Authors

  • A. Lindholm
    • Department of Clinical PharmacologyHuddinge Hospital
    • Department of Transplantation Surgery, Karolinska InstituteHuddinge Hospital
  • S. Henricsson
    • Department of Clinical PharmacologyHuddinge Hospital
  • M. Lind
    • Department of Clinical PharmacologyHuddinge Hospital
  • R. Dahlqvist
    • Department of Clinical PharmacologyHuddinge Hospital
Originals

DOI: 10.1007/BF01046702

Cite this article as:
Lindholm, A., Henricsson, S., Lind, M. et al. Eur J Clin Pharmacol (1988) 34: 461. doi:10.1007/BF01046702

Summary

We have measured total and unbound plasma concentrations of cyclosporin A in seven healthy men after single oral doses (12 mg per kg body weight) on two occasions at least two weeks apart.

There was an up to two-fold intraindividual and a more than three-fold interindividual variation in the AUCs of both total and unbound drug.

The intraindividual variability in the AUC of cyclosporin is similar to that of many other drugs and needs to be taken into account in the planning of pharmacokinetic studies.

Key words

cyclosporin Aorgan transplantationimmunosuppressionsystemic availabilityplasma concentrationsintra-/interindividual variation
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Copyright information

© Springer-Verlag 1988