Journal of Autism and Developmental Disorders

, Volume 22, Issue 1, pp 33–45

Hyperserotoninemia and antiserotonin antibodies in autism and other disorders

Authors

  • Arthur Yuwiler
    • University of California-Los Angeles-School of Medicine
    • Neurobiochemistry Laboratory T-85West Los Angeles Veterans Administration Medical Center, Brentwood Division
  • Jean Chen Shih
    • School of PharmacyUniversity of Southern California
  • Chong-Hong Chen
    • School of PharmacyUniversity of Southern California and Anhui Medical University
  • Edward R. Ritvo
    • University of California-Los Angeles-School of Medicine
  • G. Hanna
    • University of California-Los Angeles-School of Medicine
  • G. W. Ellison
    • University of California-Los Angeles-School of Medicine
  • B. H. King
    • University of California-Los Angeles-School of Medicine
Article

DOI: 10.1007/BF01046401

Cite this article as:
Yuwiler, A., Shih, J.C., Chen, C. et al. J Autism Dev Disord (1992) 22: 33. doi:10.1007/BF01046401
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Abstract

This study examined the linkage between elevated blood serotonin in autism and the presence of circulating autoantibodies agianst the serotonin 5HT1A receptor. Information was also obtained on the diagnostic and receptor specificity of these autoantibodies. Blood serotonin was measured as was inhibition of serotonin binding to human cortical membranes by antibody-rich fractions of blood from controls and from patients with childhood autism, schizophrenia, obsessive-compulsive disorder, Tourette's, and multiple sclerosis. The results showed elevated blood serotonin was not closely related to inhibition of serotonin binding by antibody-rich blood fractions. Inhibition of binding was highest for patients with multiple sclerosis and was not specific to the 5HT1A receptor as currently defined. Although inhibition was not specific to autism, the data were insufficient to establish if people with autism differed from normal controls on this measure.

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Copyright information

© Plenum Publishing Corporation 1992