Journal of Autism and Developmental Disorders

, Volume 23, Issue 2, pp 323–339

A prevalence study of autism in tuberous sclerosis

  • Ann Hunt
  • Charles Shepherd

DOI: 10.1007/BF01046223

Cite this article as:
Hunt, A. & Shepherd, C. J Autism Dev Disord (1993) 23: 323. doi:10.1007/BF01046223


An estimate of the prevalence of autism in tuberous sclerosis (TSC) was made by interviewing the parents of 21 children between ages 3 and 11 ascertained during a previous population study of the condition in the West of Scotland. Five of the children (24%) were rated autistic and a further four (19%), all of whom were girls, has socially impaired behavior categorized as pervasive developmental disorder, without fulfilling all the DSM-III-R criteria for autism. One further boy had disruptive attention-seeking behavior that had excluded him from his, normal school. The estimated prevalence from this study of autism in TSC is 1 in 4 children in general, and 1 in 2 of those with mental retardation. Tuberous sclerosis could be a significant cause of autism and pervasive developmental disorders, particularly in girls.

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Ann Hunt
    • 2
  • Charles Shepherd
    • 1
  1. 1.Royal Hospital for Sick ChildrenGlasgow
  2. 2.Section of Child & Adolescent PsychiatryUniversity of Oxford, Park Hospital for ChildrenOxfordEngland
  3. 3.Craigavon HospitalPortadownNorthern Ireland