Article

Biotechnology Letters

, Volume 8, Issue 4, pp 253-256

First online:

Continuous acetone-butanol fermentation with high productivity by cell ultrafiltration and recycling

  • P. PierrotAffiliated withLaboratoire des Sciences du Génie Chimique, CNRS-ENSIC Institut National Polytechnique de Lorraine
  • , M. FickAffiliated withLaboratoire des Sciences du Génie Chimique, CNRS-ENSIC Institut National Polytechnique de Lorraine
  • , J. M. EngasserAffiliated withLaboratoire des Sciences du Génie Chimique, CNRS-ENSIC Institut National Polytechnique de Lorraine

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Abstract

To increase the productivity of the acetone-butanol fermentation, a hollow-fiber ultrafilter is used to separate and recycle cells in a continuous fermentation ofClostridium acetobutylicum. Under partial cell recycling and at a dilution rate of 0.5 hr−1, a cellular concentration of 20 g/l and a solvent productivity of 6.5 g/l.hr is maintained for several days at a total solvent concentration of 13 g/l.