Biotechnology Letters

, Volume 11, Issue 11, pp 765–768

Development of a fructose based medium for biosynthesis of cyclosporin-A byBeauveria nivea

Authors

  • Argyrios Margaritis
    • Department of Chemical and Biochemical EngineeringThe University of Western Ontario
  • Parminder Singh Chahal
    • Department of Chemical and Biochemical EngineeringThe University of Western Ontario
Article

DOI: 10.1007/BF01026093

Cite this article as:
Margaritis, A. & Chahal, P.S. Biotechnol Lett (1989) 11: 765. doi:10.1007/BF01026093
  • 16 Views

Summary

A new fructose based medium was developed to growBeauveria nivea ATCC 34921 for the production of Cyclosporin A (CyA). Two different sugars and three different nitrogen sources were used for CyA production. Different pH levels in the broth revealed that the best pH for CyA production was 5.5. Maximum concentration of 170 mg CyA/L of broth was obtained with the new medium in 8 days corresponding to yields of 14.8 mg CyA/g dry weight biomass and 5.67 mg CyA/g fructose supplied.

Copyright information

© Kluwer Academic Publishers 1989