Journal of Chemical Ecology

, Volume 14, Issue 10, pp 1965–1975

Plant-insect coevolution and inhibition of acetylcholinesterase

  • M. F. Ryan
  • Oonagh Byrne
Article

DOI: 10.1007/BF01013489

Cite this article as:
Ryan, M.F. & Byrne, O. J Chem Ecol (1988) 14: 1965. doi:10.1007/BF01013489

Abstract

The theory of plant-insect coevolution provides for diffuse coevolution and the expectation that plants evolve broad-spectrum chemical defenses with which some insects coevolve by detoxifying and using the compounds as host-location cues. Specific biochemical modes of action have been assigned to relatively few such defense chemicals and one major class, the terpenoids, is investigated here. Six terpenoids inhibited the enzyme acetylcholinesterase (derived from electric eel) and elicited the appropriate in vivo effects of insect paralysis and mortality. The diterpene gossypol was a reversible uncompetitive inhibitor. Five monoterpenes, representing a range of functional groups, were reversible competitive inhibitors apparently occupying at least the hydrophobic site of the enzyme's active center. Such data suggest the involvement of acetylcholinesterase in the coevolved insect response to terpenoids.

Key words

Herbivory pheromones chemical defense monoterpenes and diterpenes insect paralysis and mortality enzyme evolution coevolution acetylcholinesterase inhibition plant-insect coevolution 

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • M. F. Ryan
    • 1
  • Oonagh Byrne
    • 1
  1. 1.Department of ZoologyUniversity College DublinBelfieldIreland

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