Molecular Biology Reports

, Volume 18, Issue 1, pp 29–35

Definition of the Th/ To ribonucleoprotein by RNase P and RNase MRP

  • W. Rossmanith
  • R. Karwan
Research Articles

DOI: 10.1007/BF01006892

Cite this article as:
Rossmanith, W. & Karwan, R. Mol Biol Rep (1993) 18: 29. doi:10.1007/BF01006892


We show that the Th/ To ribonucleoprotein is defined by (i) the co-immunoprecipitation of two RNAs, (ii) the co-immunoprecipitation of four major polypeptides and (iii) the quantitative immune recognition of both RNase P and RNase MRP. No serum was found that recognizes either one of these two enzymes exelusively. The specific co-immunoprecipitation of RNase MRP and RNase P by all Th/ To ribonucleoprotein autoantibodies indicates that the anti-Th/ To autoimmune response is directed against both enzymes in a quantitatively indistinguishable manner. Thus the Th/ To ribonucleoprotein is defined by RNase P and RNase MRP.

Key words

autoantibodyautoantigenRNase PThTo

Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • W. Rossmanith
    • 1
  • R. Karwan
    • 1
  1. 1.Abt. GenexpressionInstitut für Tumorbiologie-Krebsforschung der Universität WienWienAustria