The Histochemical Journal

, Volume 22, Issue 10, pp 537–544

Keratin 19 expression in the adult and developing human mammary gland

  • J. Bartek
  • J. Bartkova
  • J. Taylor-Papadimitriou
Papers

DOI: 10.1007/BF01005976

Cite this article as:
Bartek, J., Bartkova, J. & Taylor-Papadimitriou, J. Histochem J (1990) 22: 537. doi:10.1007/BF01005976

Summary

In the adult human mammary gland, most of the luminal epithelial cells express keratin 19 (K19+). However, in some small ducts and terminal ductal lobular units where branching would be expected to occur during pregnancy, the pattern of expression of this keratin is heterogeneous. While the keratin 19 negative cells (K19−) appear to have a high proliferative potentialin vitro andin vivo, they have a lower secretory activity than the K19+ cells as monitored by expression of secretory component in the resting breast or casein in the pregnant gland.

That the K19− cells form a separate proliferative compartment in the luminal cell lineage is suggested by the fact that they are absent in the prepubertal breast and only appear at puberty associated with branching ducts, and newly formed lobules. Our observations are consistent with the hypothesis that the K19− luminal cell is less differentiated than and may be precursor to the K19+ luminal cell, which represents the fully differentiated phenotype able to produce milk in response to a hormonal stimulus.

Copyright information

© Chapman and Hall Ltd 1990

Authors and Affiliations

  • J. Bartek
    • 1
  • J. Bartkova
    • 1
  • J. Taylor-Papadimitriou
    • 1
  1. 1.Imperial Cancer Research FundLondonUK
  2. 2.Institute of Medical Research, Research Institute of Clinical and Experimental OncologyBrnoCzechoslovakia

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