Metabolic Brain Disease

, Volume 4, Issue 1, pp 61–65

The area postrema and the hypertensive effect of angiotensin

Authors

  • S. Veljković
    • Department of PharmacologyMedical Faculty
  • Danica Jovanović-Mićić
    • Department of PharmacologyMedical Faculty
  • Nina Japundžić
    • Department of PharmacologyMedical Faculty
  • Ranka Samardžić
    • Department of PharmacologyMedical Faculty
  • D. B. Beleslin
    • Department of PharmacologyMedical Faculty
Original Contributions

DOI: 10.1007/BF00999495

Cite this article as:
Veljković, S., Jovanović-Mićić, D., Japundžić, N. et al. Metab Brain Dis (1989) 4: 61. doi:10.1007/BF00999495

Abstract

The intracerebroventricular administration of angiotensin II in pentobarbital-anesthetized cats produced dose-dependent increases in the arterial blood pressure without significant changes in the heart rate. The ablation of the area postrema significantly reduced, but did not abolish, the pressor effect of angiotensin injected into the cerebral ventricles. It follows, then, that the central pressor effect of angiotensin is dependent on the integrity of the area postrema and that this central site, at least in part, contributes to the pressor action of endogenous angiotensin.

Key words

arterial blood pressureangiotensinintracerebroventricular injectionscatarea postrema

Copyright information

© Plenum Publishing Corporation 1989