Original Contributions

Metabolic Brain Disease

, Volume 4, Issue 1, pp 61-65

First online:

The area postrema and the hypertensive effect of angiotensin

  • S. VeljkovićAffiliated withDepartment of Pharmacology, Medical Faculty
  • , Danica Jovanović-MićićAffiliated withDepartment of Pharmacology, Medical Faculty
  • , Nina JapundžićAffiliated withDepartment of Pharmacology, Medical Faculty
  • , Ranka SamardžićAffiliated withDepartment of Pharmacology, Medical Faculty
  • , D. B. BeleslinAffiliated withDepartment of Pharmacology, Medical Faculty

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Abstract

The intracerebroventricular administration of angiotensin II in pentobarbital-anesthetized cats produced dose-dependent increases in the arterial blood pressure without significant changes in the heart rate. The ablation of the area postrema significantly reduced, but did not abolish, the pressor effect of angiotensin injected into the cerebral ventricles. It follows, then, that the central pressor effect of angiotensin is dependent on the integrity of the area postrema and that this central site, at least in part, contributes to the pressor action of endogenous angiotensin.

Key words

arterial blood pressure angiotensin intracerebroventricular injections cat area postrema