Thiamine deficiency and wernicke's encephalopathy in AIDS
Received: 20 November 1991 Accepted: 08 January 1992 DOI:
Cite this article as: Butterworth, R.F., Gaudreau, C., Vincelette, J. et al. Metab Brain Dis (1991) 6: 207. doi:10.1007/BF00996920 Abstract
Several neuropathological reports in the last 5 years have described brain lesions characteristic of Wernicke's Encephalopathy in patients with AIDS. Using the erythrocyte transketolase activation assay, we now report biochemical evidence of thiamine deficiency in 9/39 (23%) of patients with AIDS or AIDS-related complex. In no cases was there history of alcohol abuse nor were there clinical signs of Wernicke's Encephalopathy. Thiamine deficiency in these patients most likely results from the cachexia and catabolic state characteristic of AIDS. In view of (i) the confirmed neuropathological evidence of Wernicke's Encephalopathy in AIDS patients, (ii) the significant thiamine deficiency in these patients and (iii) the difficulties of clinical diagnosis of Wernicke's Encephalopathy, it is recommended that dietary thiamine supplementation be initiated in all newly diagnosed cases of AIDS or AIDS-related complex.
Key words AIDS AIDS-related complex thiamine deficiency Wernicke's Encephalopathy α-ketoglutarate dehydrogenase transketolase References
Butterworth R.F., Giguère J.-F., and Besnard A.-M. (1986). Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. α-ketoglutarate dehydrogenase
Butterworth R.F. (1989). Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff Syndrome.
Alcohol & Alcoholism
Butterworth R.F., Gaudreau C., Vincelette J., Bourgault A.-M., Lamothe F., and Nutini A.-M. (1991). Thiamine deficiency in AIDS.
D'Amour M.L., Bruneau J., and Butterworth R.F. (1991). Abnormalities of peripheral nerve conduction in relation to thiamine status in alcoholic patients.
Can. J. Neurol. Sci.
Davtyan D.G., and Vinters H.V. (1987). Wernicke's Encephalopathy in AIDS patient treated with Zidovudine.
Foresti V., Parisio E., Scolari N., Sparacio F., and Confalonieri F. (1986). Sindrome da immunodeficienza acquisita associata a tubercolosi disseminata ed a encefalopatia cronica di Wernicke.
Recenti Progressi in Medicina
Foresti V., and Confalonieri F. (1987). Wernicke's Encephalopathy in AIDS.
Harper C. (1979). Wernicke's Encephalopathy: a more common disease than realized.
J. Neurol. Neurosurg. Psychiat.
Heier M.S., and Fossa S.D. (1986). Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5′-dFUrd).
Acta Neurol. Scand.
Hutchin K.C. (1987). Thiamine deficiency, Wernicke's Encephalopathy and AIDS.
Kwee I.L., and Nakada T. (1983). Wernicke's Encephalopathy induced by tolazamide.
New Eng. J. Med.
Lindboe C.F., and Loberg E.M. (1989). Wernicke's Encephalopathy in non-alcoholics. An autopsy study.
J. Neurol. Sci.
Mukherjee A.B., Ghazanfari A., Svoronos S., Staton R.C., Nakata T., and Kwee I.L. (1986). Transketolase abnormality in tolazamide-induced Wernicke's Encephalopathy.
Rosemberg S., Lopes M.B.S. and Tsanaclis A.M. (1986). Neuropathology of acquired immunodeficiency syndrome (AIDS). Analysis of 22 Brazilian cases.
J. Neurol. Sci.
Parry G.J. (1988). Peripheral neuropathies associated with human immunodeficiency virus infection.
Schwenk J., Gosztonyl G., Theraulf P., Iglesias J. and Langer E. (1990). Wernicke's encephalopathy in two patients with acquired immunodeficiency syndrome.
Soffer D., Zirkin H., Alkan M. and Berginer V.M. (1989). Wernicke's encephalopathy in acquired immune deficiency syndrome (AIDS): a case report.
Torvik A., Linboe C.F. and Rodge S. (1982). Brain lesions in alcoholics. A neuropathological study with clinical correlations.
J. Neurol. Sci.
Victor M., Adams R.D., Collins G.H. (1989).
The Wernicke Korsakoff Syndrome
, F.A. Davis, Philadelphia.
Google Scholar Copyright information
© Plenum Publishing Corporation 1991