Neurochemical Research

, Volume 17, Issue 9, pp 877–885

Quantitative aspects of reactive gliosis: A review

Authors

  • W. T. Norton
    • Department of NeurologyAlbert Einstein College of Medicine
    • Department of NeuroscienceAlbert Einstein College of Medicine
  • D. A. Aquino
    • Department of NeurologyAlbert Einstein College of Medicine
  • I. Hozumi
    • Department of NeurologyAlbert Einstein College of Medicine
  • F. -C. Chiu
    • Department of NeurologyAlbert Einstein College of Medicine
    • Department of NeuroscienceAlbert Einstein College of Medicine
  • C. F. Brosnan
    • Department of NeuroscienceAlbert Einstein College of Medicine
    • Department of PathologyAlbert Einstein College of Medicine
Original Articles

DOI: 10.1007/BF00993263

Cite this article as:
Norton, W.T., Aquino, D.A., Hozumi, I. et al. Neurochem Res (1992) 17: 877. doi:10.1007/BF00993263

Abstract

Recent studies of gliosis in a variety of animal models are reviewed. The models include brain injury, neurotoxic damage, genetic diseases and inflammatory demyelination. These studies show that reactive gliosis is not a stereotypic response, but varies widely in duration, degree of hyperplasia, and time course of expression of GFAP immunostaining, content and mRNA. We conclude that there are different biological mechanisms for induction and maintenance of reactive gliosis, which, depending on the kind of tissue damage, result in different expressions of the gliotic response.

Key Words

GliosisastrocytesGFAPbrain damagedemyelination

Copyright information

© Plenum Publishing Corporation 1992