Neurochemical Research

, Volume 13, Issue 7, pp 649–655

Monomeric and polymeric forms of ependymin: A brain extracellular glycoprotein implicated in memory consolidation processes

Authors

  • Victor E. Shashoua
    • Ralph Lowell Laboratories, McLean HospitalHarvard Medical School
Original Articles

DOI: 10.1007/BF00973283

Cite this article as:
Shashoua, V.E. Neurochem Res (1988) 13: 649. doi:10.1007/BF00973283

Abstract

Ependymin, a brain extracellular glycoprotein that appears to be implicated in neural circuit modifications associated with the process of memory consolidation, can rapidly polymerize into fibrous aggregates when the Ca2+ concentration in solution is reduced by the addition of EGTA or by dialysis. Such aggregates, once formed, could not be redissolved in boiling 1% SDS in 6 M urea, acetic acid, saturated aqueous potassium thiocyanate, and trifluoroacetic acid. They were, however, soluble in formic acid. Investigations of the immunological properties of ependymin indicated that various monomers, oligomers and polymers of the molecule with differing carbohydrate contents can be obtained. The polymerization properties of the ependymins may play an important role in their functions in memory consolidation mechanisms.

Key Words

Ependyminbrain extracellular fluidglycoproteinsextracellular matrixmemory consolidation

Copyright information

© Plenum Publishing Corporation 1988