Evidence for increased lipid peroxidation in multiple sclerosis
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Pentane and ethane are degradation products of unsaturated fatty acids which are released during lipid peroxidation. In order to assess whether multiple sclerosis is associated with lipid peroxidation, we measured pentane and ethane excretion by 16 patients with multiple sclerosis and compared them to healthy control subjects. Patients with acute exacerbation of multiple sclerosis had significantly higher concentrations of pentane (10.5±4.2 nmol/l)(p<0.01) compared to either patients in remission (4.5±1.7 nmol/l) or control subjects (4.9±1.1 nmol/l). The concentrations of ethane were not significantly different among these groups. Of the patients with acute exacerbation who later achieved remission, the pentane excretion also returned to normal (5.6±0.9 nmol/l). One patient who failed to reachieve clinical remission continued to excrete large amounts of pentane. We conclude that oxygen free radical activity is enhanced during exacerbation multiple sclerosis.
- Fligiel S. E. G., Lee E. C., McCoy J. P., Johnson K. J., and Varani J. 1984. Protein degradation following treatment with hydrogen peroxide. Am. J. Pathol. 115:418–425.
- Nielsen H. K., Loliger J., and Hurrell R. F. 1985. Reactions of proteins with oxidizing lipids. Br. J. Nutr. 53:61–73.
- Freeman B. A., and Crapo J. D. 1982. Biology of Disease: free radicals and tissue injury. Lab. Invest. 47:412–426.
- Slater T. F. 1984. Overview of methods used for detecting lipid peroxidation. Meth. Enzymol. 105:283–293.
- Gavino V. C., Dillard C. J., and Tappel A. L. 1984. Release of ethane and pentane from rat tissue slices: effect of vitamin E, halogenated hydrocarbons, and iron overload. Arch. Biochem. Biophys. 233(2):741–747.
- Tappel A. L. 1973. Lipid peroxidation damage to cell components. Fed. Proc. 32:1870–74.
- Zarling E. J., and Clapper M. 1987. Technique for gas-chromatographic measurement of volatile alkanes from single-breath. samples. Clin. Chem., 33:140–141.
- Riely C. A., Cohen G., and Lieberman M. 1974. Ethane evolution: A new index of lipid peroxidation. Science 183:208–210.
- Dillard C. J., Litov R. E., Savin W. M., Dumelin E. E., and Tappel A. L. 1978. Effects of exercise, vitamin E, and ozone on pulmonary function and lipid peroxidation. J. Appl. Physiol. 45:927–932.
- Humad S., Zarling E. J., Clapper M., and Skosey J. L. 1988. Breath pentane excretion as a marker of disease activity in rheumatoid arthritis. Free. Rad. Res. Comms. 5:101–106.
- Dillard C. J., and Tappel A. L. 1979. Volatile hydrocarbon and carbonyl products of lipid peroxidation: A comparison of pentane, ethane, hexanal, and acetone as in vivo indices. Lipids. 14:989–995.
- Wispe J. R., Bell E. F., and Roberts R. J. 1985. Assessment of lipid peroxidation in newborn infants and rabbits by measurements of expired ethane and pentane: Influence of parenteral lipid infusion. Pediatr. Res. 19:374–379.
- Mickel H. S. 1975. Multiple Sclerosis: A new hypothesis. Perspective in Biology and Medicine. 363–374.
- Chan P. H., Fishman P. A., Schmidley J. W., and Chen S. F. 1984. Release of polyusaturated fatty acids from phospholipids and alteration of brain membrane integrity by oxygen-derived free radicals. J. Neurosci. Res. 12:595–605.
- Baker R. W. R., Thompson R. H. S., Zilkha K. J. 1963. Fatty-acid composition of brain lecithins in multiple sclerosis. Lancet. 1:26–27.
- Nishida T., Tsuchiyama H., Inoue M., and Kummerow F. A. 1960. Effect of intravenous injection of oxidized methyl esters of unsaturated fatty acids on chick encephalomalacia. Proc. Soc. Exp. Biol. Med. 105:308–312.
- Bowern N., Ramshaw I. A., Clark I. A., and Doherty P. C. 1984. Inhibition of autoimmune neuropathological process by treatment with an iron-chelating agent. J. Exp. Med. 160:1532–1543.
- Arnetoli G., Pazzagli A., Amaducci L. 1969. Fatty acid and aldehyde changes in choline-and ethanolamine-containing phospholipase in the white matter of multiple sclerosis brains. J. Neurochem. 16:461–463.
- Thaw H. H., Collins V. P., Brunk U. T. 1984. Influence of oxygen tension, prooxidants and antioxidants on the formation of lipid peroxidation products (lipofuscin) in individual cultivated human glial cells. Mechanisms of ageing and development 24:211–223.
- Sokol R. J. 1988. Vitamin deficiency and neurologic disease. Ann. Rev. Nutr. 8:351–73.
- Konat G. W., and Wiggins R. C. 1985. Effect of reactive oxygen species on myelin membrane proteins. J. Neurochem. 45:1113–1118.
- Srebro Z., Cichoki T., and Godula J. 1971. Peroxidase activity in glia and ependymocytes of the mouse brain. Acta Morphologica. Acad. Sci. Hung. 19:389–395.
- Demopoulos H. B., Flamm E. S., Seligman M. L., Pietronigro D. D., Tomasula J., and DeCrescito V. 1982. Further studies on free-radical pathology in the major central nervous system disorders: effect of very high doses of methylprednisone on the functional outcome, morphology, and chemistry of experimental spinal cord impact injury. Can. J. Physiol. Pharmacol. 60:1415–1424.
- Evidence for increased lipid peroxidation in multiple sclerosis
Volume 17, Issue 2 , pp 205-207
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- lipid peroxidation
- free radicals
- multiple sclerosis
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