, Volume 16, Issue 9, pp 1085-1097

Cerebral circulation revisited: An historical essay

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Abstract

Three centuries of investigations relevant to cerebral circulation, from the discoveries of circulation by Harvey (1628) and Willis (1664) to the 2-deoxyglucose methods of Sokoloff (1977), have been surveyed. Perspective is provided from discussion of such developments as: the discovery of oxygen and its role in combustion, respiration and cellular metabolism; recognition of the blood-brain barrier especially as selective exchange transport systems; introduction of the concept of metabolism and elucidation of details of glycolysis and oxidative phosphorylation; the discovery of neurotransmitters and an understanding of the ionic bases for conduction and neural activity; and introduction of modern techniques for studying cerebral circulation and metabolism, specifically, the Kety-Schmidt N2O method and the Sokoloff [14C]deoxyglucose autoradiographic method for regional and local applications, with subsquent adaptation to PET studies in situ.

National Institute of Neurological Disorders and Stroke, NIH.
Special issue dedicated to Dr. Louis Sokoloff.