Neurochemical Research

, Volume 16, Issue 9, pp 1055–1058

Fluoroacetate and fluorocitrate: Mechanism of action

  • Donald D. Clarke
Original Articles

DOI: 10.1007/BF00965850

Cite this article as:
Clarke, D.D. Neurochem Res (1991) 16: 1055. doi:10.1007/BF00965850


The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a “suicide” substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glialneuronal relationships is considered.

Key Words

Fluoroacetate fluorocitrate fluoroaconitate 

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Donald D. Clarke
    • 1
  1. 1.Department of ChemistryFordham UniversityBronxU.S.A.