Fluoroacetate and fluorocitrate: Mechanism of action
- Cite this article as:
- Clarke, D.D. Neurochem Res (1991) 16: 1055. doi:10.1007/BF00965850
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The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a “suicide” substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glialneuronal relationships is considered.