Neurochemical Research

, Volume 19, Issue 9, pp 1131–1137

Evidence of an oxidative challenge in the Alzheimer's brain

  • Louisa Balazs
  • Michael Leon
Original Articles

DOI: 10.1007/BF00965146

Cite this article as:
Balazs, L. & Leon, M. Neurochem Res (1994) 19: 1131. doi:10.1007/BF00965146

Abstract

Alzheimer's disease may arise from or produce oxidative damage in the brain. To assess the responses of the Alzheimer's brain to possible oxidative challenges, we assayed for glutathione, glucose-6-phosphate dehydrogenase, catalase and superoxide dismutase in twelve regions of Alzheimer's disease and aged control brains. In addition, we determined levels of malondialdehyde to evaluate lipid peroxidation in these brain regions. Most brain regions showed evidence of a response to an oxidative challenge, but the cellular response to this challenge differed among brain regions. These data suggest that the entire Alzheimer's brain may be subject to an oxidative challenge, but that some brain areas may be more vulnerable than others to the consequent neural damage that characterizes the disease.

Key Words

Alzheimer's diseaseglucose-6-phosphate dehydrogenaseglutathionesuperoxide dismutasecatalasemalondialdehydelipid peroxidation

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Louisa Balazs
    • 1
  • Michael Leon
    • 1
  1. 1.Department of PathologyUniversity of Tennessee College of MedicineMemphis
  2. 2.Department of PsychobiologyUniversity of CaliforniaIrvine