Neurochemical Research

, Volume 9, Issue 8, pp 1039–1049

Selective alteration of neurotransmitter release by low oxygen in vitro

  • Joseph A. Hirsch
  • Gary E. Gibson
Original Articles

DOI: 10.1007/BF00964800

Cite this article as:
Hirsch, J.A. & Gibson, G.E. Neurochem Res (1984) 9: 1039. doi:10.1007/BF00964800


The potassium-stimulated release of acetylcholine, norepinephrine, serotonin, glutamate, and 4-aminobutyrate from superfused rat cortical slices was studied during hypoxia. A reduction in oxygen tensions from 603±6 to 22±2 mm Hg selectively altered the calcium-dependent efflux of these neurotransmitters, but did not change their calcium-independent release. The calcium-dependent release of [14C]acetylcholine decreased (39%), while that of glutamate increased (66%) and 4-aminobutyrate, [3H]norepinephrine, and [3H]serotonin were unaffected. Thus, low oxygen reveals variations in the calcium-dependent release mechanisms of several neurotransmitters. These differences may have important implications for pharmacological intervention of neurotransmitter release.

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Joseph A. Hirsch
    • 1
  • Gary E. Gibson
    • 1
  1. 1.Department of NeurologyCornell University Medical College The Burke Rehabilitation CenterWhite Plains

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