Neurochemical Research

, Volume 5, Issue 3, pp 301–308

Aging and rat brain muscarinic receptors as measured by quinuclidinyl benzilate binding

  • Anne M. Morin
  • Claude G. Wasterlain
Original Articles

DOI: 10.1007/BF00964618

Cite this article as:
Morin, A.M. & Wasterlain, C.G. Neurochem Res (1980) 5: 301. doi:10.1007/BF00964618

Abstract

Measurement of cholinergic muscarinic receptor binding in various rat brain areas using the ligand [3H]quinuclidinyl benzilate indicates that receptor binding is decreased in striatum and cerebellum of aged female rats (22 months old) as compared to younger rats (4 months old). Decreases were not observed in cortex, hippocampus, hypothalamus, or amygdala areas. Further examination of [3H]quinuclidinyl benzilate binding in subcellular fractions of aged and young rat cerebellum and striatum indicated a decrease in binding in the crude nuclear and crude synaptosomal fractions. Binding data indicate the observed decrease in specific ligand binding is due to a decrease in number of binding sites while receptor affinity does not appear to change.

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Anne M. Morin
    • 2
    • 1
  • Claude G. Wasterlain
    • 2
    • 1
  1. 1.Epilepsy Research LaboratoryVeterans Administration Medical CenterSepulveda
  2. 2.Department of Neurology and Brain Research Institute School of MedicineUniversity of CaliforniaLos Angeles