Neurochemical Research

, Volume 4, Issue 2, pp 223–239

The role of thiamine in nervous tissue

  • Jack R. Cooper
  • Jonathan H. Pincus
Original Articles

DOI: 10.1007/BF00964146

Cite this article as:
Cooper, J.R. & Pincus, J.H. Neurochem Res (1979) 4: 223. doi:10.1007/BF00964146


The possibility that thiamine (vitamin B1) has a role in nervous tissue that is independent of its well-documented coenzyme function is discussed. After reviewing the localization and metabolism of the vitamin and its phosphate esters, the effects of either thiamine deprivation or antimetabolites of thiamine on conduction and transmission, and the relationship between thiamine triphosphate and the genetic, neurological disease, subacute necrotizing encephalomyelopathy (Leigh's disease), it is suggested that despite the lack of hard evidence, it is likely that the vitamin possesses this alternate function.

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Jack R. Cooper
    • 1
  • Jonathan H. Pincus
    • 1
  1. 1.Departments of Pharmacology and NeurologyYale University School of MedicineNew Haven

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