Ubiquinone supplementation and exercise capacity in trained young and older men

  • R. Laaksonen
  • M. Fogelholm
  • J. -J. Himberg
  • J. Laakso
  • Y. Salorinne
Original Article

DOI: 10.1007/BF00964121

Cite this article as:
Laaksonen, R., Fogelholm, M., Himberg, J.J. et al. Eur J Appl Physiol (1995) 72: 95. doi:10.1007/BF00964121

Abstract

It has been suggested that ubiquinone improves exercise performance and antioxidant capacity. We studied the effects of ubiquinone supplementation (120 mg · day−1 for 6 weeks) on aerobic capacity and lipid peroxidation during exercise in 11 young (aged 22–38 years) and 8 older (aged 60–74 years), trained men. The cross-over study was double-blind and placebo-controlled. Serum ubiquinone concentration increased after supplementation (P < 0.0001 for treatment) in both age groups. The maximal oxygen uptake (\(\dot VO_{2\max } \)) was measured using a direct incremental ergometer test. In the young subjects, the\(\dot VO_{2\max } \) after placebo and ubiquinone treatment was 58.5 (95% confidence interval: 53.0–64.0) and 59.0 ml · min−1 · kg−1 (52.2–66.8), respectively. The corresponding results in the older subjects were: 37.2 (31.7–42.7) and 33.7 ml · min−1 · kg−1 (26.2–41.7) (P < 0.0001 for age group,P > 0.05 for treatment). In a prolonged test (60-min submaximal, then incremental load until exhaustion) time to exhaustion was longer after the placebo [young men: 85.7 (82.4–89.0), older men: 82.9 min (75.8–89.9)] than after ubiquinone [young men: 82.1 (78.5–85.8), older men: 77.2 min (70.1–83.7);P = 0.0003 for treatment]. Neither ubiquinone supplementation nor exercise affected serum malondialdehyde concentration. Oral ubiquinone was ineffective as an ergogenic aid in both the young and older, trained men.

Key words

Aging Antioxidants Coenzyme Q10 Ergogenic aids Lipid peroxidation 

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • R. Laaksonen
    • 1
  • M. Fogelholm
    • 2
  • J. -J. Himberg
    • 1
  • J. Laakso
    • 3
  • Y. Salorinne
    • 4
  1. 1.University of HelsinkiDepartment of Clinical PharmacologyHelsinkiFinland
  2. 2.The UKK Institute for Health Promotion ResearchTampereFinland
  3. 3.MILA Laboratory, Ltd.HelsinkiFinland
  4. 4.Department of Clinical PhysiologyLaakso HospitalHelsinkiFinland

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